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ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.


eISSN: 1857-9655

Clinical Science




Indicators of Asthma Control in Asthmatic Patients: Are they related to Depression?

Tarig H. Merghani*, Azza O. Alawad


Department of Physiology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia





BACKGROUND: Many patients with chronic illnesses suffer from depression. A poorly controlled asthma that presents with repeated attacks of breathlessness is a recognised risk factor for bipolar disorders. On the other hand, depression can aggravate asthma symptoms.

AIM: The aim of this study is to determine the indicators of the asthma control test (ACT) among the asthmatic patients who attend the outpatient clinic for follow-up and to investigate the relation between these indicators and clinical depression, using a standardised depression scale.

METHODS: A total of 38 adult asthmatic patients (29 women, age 17–85 years), with variable levels of control, were assessed using the ACT and the Beck Depression Inventory (BDI). Data obtained were analysed with the Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, USA) version 20. The association of depression with the various indicators of asthma control was analysed with the Chi-Square test. Statistical significance was determined at p< 0.05.

RESULTS: The uncontrolled asthma is associated with depression in 37% of all participants compared to 0% in the well-controlled group (p = 0.002). Depression is significantly related to asthma interference with daily activities (p = 0.003), breathlessness (p < 0.001), night symptoms (p = 0.036), use of bronchodilators (p = 0.007), and poor compliance with medical treatment (p = 0.003). The poor educational attainment and comorbidities have significant relations to both uncontrolled asthma and clinical depression (p < 0.05).

CONCLUSION: All indicators of the poor asthma control are associated with clinical depression. A significant proportion of the uncontrolled asthma patients suffers from depression. The possibility of improving asthma control with a pharmacological treatment of depression has to be considered.


Citation: Merghani TH, Alawad AO. Indicators of Asthma Control in Asthmatic Patients: Are they related to Depression? Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.091
Keywords: Asthma; Depression; Asthma Control.
*Correspondence: Tarig H. Merghani. Department of Physiology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia. E-mail: tarighm@gmail.com
Received: 07-May-2017; Revised: 05-Jun-2017; Accepted: 06-Jun-2017; Online first: 18-Jun-2017
Copyright: 2017 Tarig H. Merghani, Azza O. Alawad. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: The Deanship of Scientific Research (DSR), the University of Tabuk, Tabuk, Saudi Arabia.
Competing Interests: Publication of this paper has been supported by Roche Macedonia DOOEL Skopje.


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Published by: Id Design 2012/DOOEL Skopje, Republic of Macedonia

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.