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Open Access Macedonian Journal of Medical Sciences.
Association of the Pro12Ala
Polymorphism with the Metabolic Parameters in Women with Polycystic Ovary
Moushira Zaki1*, Naglaa Hassan1,
Hala T. El-Bassyouni2, Sanaa Kamal1, Walaa Basha1,
Osama Azmy3, Khalda Amr4
Anthropology Department, National Research Centre, Cairo, Egypt; 2Clinical
Genetics Department, National Research Centre, Cairo, Egypt; 3Reproductive
Health Research Department, National Research Centre, Cairo, Egypt; 4Molecular
Genetics Department, National Research Centre, Cairo, Egypt
investigate the association of peroxisome proliferator-activated receptor
gamma (PPARG) Pro12Ala polymorphism with polycystic ovary syndrome (PCOS)
and its effect on the metabolic parameters in PCOS women.
The study used PCR to identify the presence of the PPARG Pro12Ala
polymorphism in 100 PCOS women and 120 age-matched healthy women. All
participants were subjected to anthropometry, biochemical and metabolic
Significant difference in the genotypes distributions of PPARG
Pro12Ala polymorphism was observed among PCOS women and controls (p = 0.03).
The frequency of the polymorphic allele Ala was significantly higher in PCOS
cases than that in the controls (OR = 2.01, p = 0.01). The carries of the
variant allele Ala in PCOS women showed significant higher values in body
mass index (BMI), systolic and diastolic blood pressure, waist
circumference, waist to hip ratio, sum of skin folds, fasting blood glucose,
fasting blood insulin, HOMA-IR, fasting triglycerides, total cholesterol and
low-density lipoprotein than non-carriers.
The PPARG Pro12Ala polymorphism might contribute to the risk of PCOS
and abnormal metabolic parameters and could be considered as a biomarker for
early diagnosis and clinic prediction of metabolic complications.
Citation: Zaki M, Hassan N, El-Bassyouni HT, Kamal
S, Basha W, Azmy O, Amr K. Association of the Pro12Ala Polymorphism with the
Metabolic Parameters in Women with Polycystic Ovary Syndrome. Open Access
Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.088
Keywords: PCOS; metabolic; parameters; PPARG; polymorphism.
*Correspondence: Moushira Zaki. Biological Anthropology Department,
National Research Centre, Cairo, Egypt. E-mail: email@example.com
Received: 02-Apr-2017; Revised: 21-Apr-2017; Accepted: 22-Apr-2017; Online
Copyright: © 2017 Moushira Zaki, Naglaa Hassan, Hala T. El-Bassyouni,
Sanaa Kamal, Walaa Basha, Osama Azmy, Khalda Amr. This is an open-access article distributed
under the terms of the Creative Commons Attribution-NonCommercial 4.0
International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: Publication of this paper has been supported by
Roche Macedonia DOOEL Skopje.
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- Zaki M
- Hassan N
- El-Bassyouni HT
- Kamal S
- Basha W
- Azmy O
- Amr K