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ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.

https://doi.org/10.3889/oamjms.2017.088

eISSN: 1857-9655

Basic Science

 

 

 

Association of the Pro12Ala Polymorphism with the Metabolic Parameters in Women with Polycystic Ovary Syndrome


 

Moushira Zaki1*, Naglaa Hassan1, Hala T. El-Bassyouni2, Sanaa Kamal1, Walaa Basha1, Osama Azmy3, Khalda Amr4

 

1Biological Anthropology Department, National Research Centre, Cairo, Egypt; 2Clinical Genetics Department, National Research Centre, Cairo, Egypt; 3Reproductive Health Research Department, National Research Centre, Cairo, Egypt; 4Molecular Genetics Department, National Research Centre, Cairo, Egypt

 

Abstract

 

 

AIM: To investigate the association of peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism with polycystic ovary syndrome (PCOS) and its effect on the metabolic parameters in PCOS women.

METHODS: The study used PCR to identify the presence of the PPARG Pro12Ala polymorphism in 100 PCOS women and 120 age-matched healthy women. All participants were subjected to anthropometry, biochemical and metabolic evaluation.

RESULTS: Significant difference in the genotypes distributions of PPARG Pro12Ala polymorphism was observed among PCOS women and controls (p = 0.03). The frequency of the polymorphic allele Ala was significantly higher in PCOS cases than that in the controls (OR = 2.01, p = 0.01). The carries of the variant allele Ala in PCOS women showed significant higher values in body mass index (BMI), systolic and diastolic blood pressure, waist circumference, waist to hip ratio, sum of skin folds, fasting blood glucose, fasting blood insulin, HOMA-IR, fasting triglycerides, total cholesterol and low-density lipoprotein than non-carriers.

CONCLUSION: The PPARG Pro12Ala polymorphism might contribute to the risk of PCOS and abnormal metabolic parameters and could be considered as a biomarker for early diagnosis and clinic prediction of metabolic complications.

 

..................

Citation: Zaki M, Hassan N, El-Bassyouni HT, Kamal S, Basha W, Azmy O, Amr K. Association of the Pro12Ala Polymorphism with the Metabolic Parameters in Women with Polycystic Ovary Syndrome. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.088
Keywords: PCOS; metabolic; parameters; PPARG; polymorphism.
*Correspondence: Moushira Zaki. Biological Anthropology Department, National Research Centre, Cairo, Egypt. E-mail: moushiraz@yahoo.com
Received: 02-Apr-2017; Revised: 21-Apr-2017; Accepted: 22-Apr-2017; Online first: 13-Jun-2017
Copyright: 2017 Moushira Zaki, Naglaa Hassan, Hala T. El-Bassyouni, Sanaa Kamal, Walaa Basha, Osama Azmy, Khalda Amr. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: Publication of this paper has been supported by Roche Macedonia DOOEL Skopje.
 

 

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- Zaki M
- Hassan N
- El-Bassyouni HT
- Kamal S
- Basha W
- Azmy O
- Amr K


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- Zaki M
- Hassan N
- El-Bassyouni HT
- Kamal S
- Basha W
- Azmy O
- Amr K

 

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Published by: Id Design 2012/DOOEL Skopje, Republic of Macedonia


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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.