ID Design 2012/DOOEL Skopje, Republic of
Open Access Macedonian Journal of Medical Sciences.
Study of Visfatin Level in Type
1 Diabetic Children and Adolescents
Mona H. El Samahi1, Nagwa
Abdallah Ismail2, Randa M. Matter1, Abeer Selim2*,
Alshaymaa Ahmed Ibrahim3, Walaa Nabih2
Department and Pediatric Endocrinology, Faculty of Medicine, Ain Shams
University, Cairo, Egypt; 2Pediatrics Department, National
Research Centre, Cairo, Egypt; 3Clinical Pathology Department,
National Research Centre, Cairo, Egypt
Visfatin is an intracellular enzyme, known as nicotinamide
phosphoribosyltransferase (Nampt) and pre-B-cell colony-enhancing factor
(PBEF-1). It has insulin-mimetic effects and lowers plasma glucose levels.
The aim of the work was to assess serum concentration of Visfatin in type 1
diabetic children and adolescents and study its relationships with duration
of diabetes, body mass index (BMI), glycemic control, insulin dosage, lipid
profile and microvascular complications.
MATERIAL AND METHODS:
Fifty children and adolescents with type 1 diabetes mellitus were recruited
with 30 ages and gender-matched healthy subjects. They were subjected to
history taking; anthropometric measurements and chronic diabetic
complications were recorded if present. Laboratory analysis included urinary
microalbumin, serum triglycerides, HDL, LDL, cholesterol, fasting blood
glucose, glycosylated Hb (HbA1c) and serum visfatin which was measured with
enzyme-linked immunosorbent assay.
Diabetic patients showed highly significant decrease in the level of
visfatin compared to the control group (P = 0.0001).There was significant
further decrease in visfatin level in diabetics with microalbuminuria (n =
13) compared to normoalbuminuric patients (n = 37) (P = 0.015). There was
highly significant inverse correlation between visfatin level with age (r =
-0.379, p = 0.007), BMI (r = -0.418, p = 0.003), waist circumference (r =
-0.430, p = 0.002), hip circumference (r = -0.389, p = 0.005) and
microalbuminuria (r = -0.323, p = 0.022).
1 diabetic children and adolescents had a significantly lower visfatin level
compared to controls. A marked decrease in the level of visfatin was shown
in patients with microalbuminuria with an inverse correlation with BMI
suggesting an important role of visfatin in the pathogenesis of type 1
diabetics and type 1 diabetic nephropathy.
Citation: El Samahi MH, Ismail NA, Matter RM,
Selim A, Ibrahim AA, Nabih W. Study of Visfatin Level in Type 1 Diabetic
Children and Adolescents. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.065
Keywords: Type 1 diabetes; Visfatin; complications; microalbuminuria.
*Correspondence: Abeer Selim. Pediatrics Department, National
Research Centre, Cairo, Egypt. E-mail: firstname.lastname@example.org
Received: 21-Feb-2017; Revised: 12-Apr-2017; Accepted: 18-Apr-2017; Online
Copyright: © 2017 Mona H. El Samahi, Nagwa Abdallah Ismail, Randa M.
Matter, Abeer Selim, Alshaymaa Ahmed Ibrahim, Walaa Nabih. This is an open-access article
distributed under the terms of the Creative Commons Attribution-NonCommercial
4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing
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El Samahi MH
- El Samahi MH
- Ismail NA
- Matter RM
- Selim A
- Ibrahim AA
- Nabih W