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ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.

https://doi.org/10.3889/oamjms.2017.065

eISSN: 1857-9655

Clinical Science

 

 

 

Study of Visfatin Level in Type 1 Diabetic Children and Adolescents


 

Mona H. El Samahi1, Nagwa Abdallah Ismail2, Randa M. Matter1, Abeer Selim2*, Alshaymaa Ahmed Ibrahim3, Walaa Nabih2


1Pediatrics Department and Pediatric Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Pediatrics Department, National Research Centre, Cairo, Egypt; 3Clinical Pathology Department, National Research Centre, Cairo, Egypt

 

Abstract

 

 

BACKGROUND: Visfatin is an intracellular enzyme, known as nicotinamide phosphoribosyltransferase (Nampt) and pre-B-cell colony-enhancing factor (PBEF-1). It has insulin-mimetic effects and lowers plasma glucose levels.

AIM: The aim of the work was to assess serum concentration of Visfatin in type 1 diabetic children and adolescents and study its relationships with duration of diabetes, body mass index (BMI), glycemic control, insulin dosage, lipid profile and microvascular complications.

MATERIAL AND METHODS: Fifty children and adolescents with type 1 diabetes mellitus were recruited with 30 ages and gender-matched healthy subjects. They were subjected to history taking; anthropometric measurements and chronic diabetic complications were recorded if present. Laboratory analysis included urinary microalbumin, serum triglycerides, HDL, LDL, cholesterol, fasting blood glucose, glycosylated Hb (HbA1c) and serum visfatin which was measured with enzyme-linked immunosorbent assay.

RESULTS: Diabetic patients showed highly significant decrease in the level of visfatin compared to the control group (P = 0.0001).There was significant further decrease in visfatin level in diabetics with microalbuminuria (n = 13) compared to normoalbuminuric patients (n = 37) (P = 0.015). There was highly significant inverse correlation between visfatin level with age (r = -0.379, p = 0.007), BMI (r = -0.418, p = 0.003), waist circumference (r = -0.430, p = 0.002), hip circumference (r = -0.389, p = 0.005) and microalbuminuria (r = -0.323, p = 0.022).

CONCLUSIONS: Type 1 diabetic children and adolescents had a significantly lower visfatin level compared to controls. A marked decrease in the level of visfatin was shown in patients with microalbuminuria with an inverse correlation with BMI suggesting an important role of visfatin in the pathogenesis of type 1 diabetics and type 1 diabetic nephropathy.


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Citation: El Samahi MH, Ismail NA, Matter RM, Selim A, Ibrahim AA, Nabih W. Study of Visfatin Level in Type 1 Diabetic Children and Adolescents. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.065
Keywords: Type 1 diabetes; Visfatin; complications; microalbuminuria.
*Correspondence: Abeer Selim. Pediatrics Department, National Research Centre, Cairo, Egypt. E-mail: abeerselim2004@yahoo.com
Received: 21-Feb-2017; Revised: 12-Apr-2017; Accepted: 18-Apr-2017; Online first: 11-Jun-2017
Copyright: 2017 Mona H. El Samahi, Nagwa Abdallah Ismail, Randa M. Matter, Abeer Selim, Alshaymaa Ahmed Ibrahim, Walaa Nabih. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing interests exist.
 

 

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- El Samahi MH
- Ismail NA
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- Ibrahim AA
- Nabih W


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- Matter RM
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Published by: Id Design 2012/DOOEL Skopje, Republic of Macedonia


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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.