[International] [Peer Reviewed] 

About OAMJMS

Our policies

OAMJMS Online

For contributors

Services

Why publish in OAMJMS?
Editors
Boards
Publication fee
Indexing
Membership
Evaluation

Editorial & publishing policies
Competing interests policy 
Open access
Open access license

Reviewer guidelines
CrossCheck Plagiarism Screening
CrossMark Policy Page

Online first
Current issue
Journal archive

Online first fact sheet
Free Registration
Contact
Webmail

Guidelines  [pdf]
Online submission MC
Online submission OJS
Help for authors
Cover letter
Reviewers of OAMJMS

Reviewer Summary

Transliteration
Subscriptions

Sponsors
Reprints and permissions
Resources
ICMJE Disclosure Form

OTHER SOURCES: | Official Website | PubMed Central | Europe PMC | PMC Canada | PubMed | DOAJ | De Gruyter | Former MJMS |

 

ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.

https://doi.org/10.3889/oamjms.2017.055
eISSN: 1857-9655

Clinical Science

 

 

 

Voiding Urosonography with Second-Generation Ultrasound Contrast Agent for Diagnosis of Vesicoureteric Reflux: First Local Pilot Study


 

Dafina Kuzmanovska1*, Aleksandar Risteski2, Margarita Kambovska2, Tase Trpcevski2, Emilija Sahpazova1, Mile Petrovski3


1University Children’s Hospital, Medical Faculty, Ss Cyril and Methodius University of Skopje, Vodnjanska 17, Skopje, Republic of Macedonia; 2Private Hospital Plodnost, ASNOM 9, Bitola, Republic of Macedonia; 3University Pediatric Surgery Clinic, Medical Faculty, Ss Cyril and Methodius University of Skopje, Vodnjanska 17, Skopje, Republic of Macedonia

 

Abstract

 

 

BACKGROUND: Vesicoureteric reflux (VUR) is an important association of paediatric urinary tract infection (UTI) found in 30-50% of all children presenting with first UTI. Contrast-enhanced voiding ultrasonography (ceVUS) has become an important radiation-free method for VUR detection in children. Its sensitivity in detecting VUR has greatly improved due to the development of the contrast-specific ultrasound techniques and the introduction of the second-generation ultrasound contrast agent, superseding the diagnostic accuracy of standard radiological procedures.

AIM: This article aimed to summarise the current literature and discuss the first local pilot study performed in our institution on detection of vesicoureteric reflux by contrast-enhanced voiding ultrasonography with second- generation agent (SonoVue, Bracco, Italy).

MATERIAL AND METHODS: Retrospective review of the first 31 ceVUS (24 girls, 7 boys) was presented. Age range was 2 months to 18 years (mean = 6.4 ± 4.9).

RESULTS: All examinations were well tolerated without any adverse incident. VUR was shown in 20 (64.5%) children in 32/62 (51.6) nephroureteral units (NUUs). In 18 NUUs, VUR was grade II/V, in 11 Grade III/V and in 3 grade IV/V, respectively. Urethra was shown in 19/31 children and in all boys, without pathological finding. In two girls spinning top urethra has been detected. Subsequent urodynamic studies revealed functional bladder problem in both.

CONCLUSIONS: Contrast-enhanced voiding urosonography using intravesical second generation ultrasound contrast agent could be recommend as a valid alternative diagnostic modality for detecting vesicoureteral reflux and evaluation of the distal urinary tract in children, based on its radiation-free, highly efficacious, reliable, and safe characteristics.

..................

Citation: Kuzmanovska D, Risteski A, Kambovska M, Trpcevski T, Sahpazova E, Petrovski M. Voiding Urosonography with Second-Generation Ultrasound Contrast Agent for Diagnosis of Vesicoureteric Reflux: First Local Pilot Study. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.055
Keywords: Vesicoureteric reflux (VUR); pediatric urinary tract infection; Fluoroscopic voiding uretrocystography; radionuclide cystography; Contrast-enhanced voiding urosonography (ceVUS).
*Correspondence: Dafina Kuzmanovska. University Children’s Hospital, Medical Faculty, Ss Cyril and Methodius University of Skopje, Vodnjanska 17, Skopje, Republic of Macedonia. E-mail: kuzmanovska.dafina@gmail.com
Received: 20-Feb-2017; Revised: 23-Mar-2017; Accepted: 24-Mar-2017; Online first: 11-Apr-2017
Copyright: © 2017 Dafina Kuzmanovska, Aleksandar Risteski, Margarita Kambovska, Tase Trpcevski, Emilija Sahpazova, Mile Petrovski. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing interests exist.
 

 

< Previous | Next Article >

Table of contents

 

This Article (free)

Full text (pdf)

Full text OnlineFirst (pdf)


Google Scholar

- Kuzmanovska D
- Risteski A
- Kambovska M
- Trpcevski T
- Sahpazova E
- Petrovski M


PubMed

- Kuzmanovska D
- Risteski A
- Kambovska M
- Trpcevski T
- Sahpazova E
- Petrovski M

 

Altmetric
 

 


Published by: Id Design 2012/DOOEL Skopje, Republic of Macedonia


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.