ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
https://doi.org/10.3889/oamjms.2017.055
eISSN: 1857-9655
Clinical Science
|
|
Voiding Urosonography with
Second-Generation Ultrasound Contrast Agent for Diagnosis of Vesicoureteric
Reflux: First Local Pilot Study
Dafina Kuzmanovska1*, Aleksandar Risteski2,
Margarita Kambovska2, Tase Trpcevski2, Emilija
Sahpazova1, Mile Petrovski3
1University Children’s Hospital, Medical Faculty, Ss Cyril and
Methodius University of Skopje, Vodnjanska 17, Skopje, Republic of
Macedonia; 2Private Hospital Plodnost, ASNOM 9, Bitola, Republic
of Macedonia; 3University Pediatric Surgery Clinic, Medical
Faculty, Ss Cyril and Methodius University of Skopje, Vodnjanska 17, Skopje,
Republic of Macedonia
BACKGROUND: Vesicoureteric reflux (VUR) is an important association
of paediatric urinary tract infection (UTI) found in 30-50% of all children
presenting with first UTI. Contrast-enhanced voiding ultrasonography (ceVUS)
has become an important radiation-free method for VUR detection in children.
Its sensitivity in detecting VUR has greatly improved due to the development
of the contrast-specific ultrasound techniques and the introduction of the
second-generation ultrasound contrast agent, superseding the diagnostic
accuracy of standard radiological procedures.
AIM: This article aimed to summarise the current literature and
discuss the first local pilot study performed in our institution on
detection of vesicoureteric reflux by contrast-enhanced voiding
ultrasonography with second- generation agent (SonoVue, Bracco, Italy).
MATERIAL AND METHODS: Retrospective review of the first 31 ceVUS (24
girls, 7 boys) was presented. Age range was 2 months to 18 years (mean = 6.4
± 4.9).
RESULTS: All examinations were well tolerated without any adverse
incident. VUR was shown in 20 (64.5%) children in 32/62 (51.6)
nephroureteral units (NUUs). In 18 NUUs, VUR was grade II/V, in 11 Grade
III/V and in 3 grade IV/V, respectively. Urethra was shown in 19/31 children
and in all boys, without pathological finding. In two girls spinning top
urethra has been detected. Subsequent urodynamic studies revealed functional
bladder problem in both.
CONCLUSIONS: Contrast-enhanced voiding urosonography using
intravesical second generation ultrasound contrast agent could be recommend
as a valid alternative diagnostic modality for detecting vesicoureteral
reflux and evaluation of the distal urinary tract in children, based on its
radiation-free, highly efficacious, reliable, and safe characteristics.
..................
Citation: Kuzmanovska D, Risteski A, Kambovska M,
Trpcevski T, Sahpazova E, Petrovski M. Voiding Urosonography with
Second-Generation Ultrasound Contrast Agent for Diagnosis of Vesicoureteric
Reflux: First Local Pilot Study. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.055
Keywords: Vesicoureteric reflux (VUR); pediatric urinary tract
infection; Fluoroscopic voiding uretrocystography; radionuclide cystography;
Contrast-enhanced voiding urosonography (ceVUS).
*Correspondence: Dafina Kuzmanovska. University Children’s Hospital,
Medical Faculty, Ss Cyril and Methodius University of Skopje, Vodnjanska 17,
Skopje, Republic of Macedonia. E-mail: kuzmanovska.dafina@gmail.com
Received: 20-Feb-2017; Revised: 23-Mar-2017; Accepted: 24-Mar-2017; Online
first: 11-Apr-2017
Copyright: © 2017 Dafina Kuzmanovska, Aleksandar Risteski, Margarita
Kambovska, Tase Trpcevski, Emilija Sahpazova, Mile Petrovski. This is an
open-access article distributed under the terms of the Creative Commons
Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing
interests exist.
|
<
Previous
|
Next Article >
Table of contents
This Article
(free)
Full text (pdf)
Full text OnlineFirst (pdf)
Google Scholar
-
Kuzmanovska D
-
Risteski A
-
Kambovska M
-
Trpcevski T
-
Sahpazova E
-
Petrovski M
PubMed
- Kuzmanovska D
- Risteski A
- Kambovska M
- Trpcevski T
- Sahpazova E
- Petrovski M
|