ID Design 2012/DOOEL Skopje, Republic of
Open Access Macedonian Journal of Medical Sciences.
Association among Thyroid
Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia
Javad Ghaffari1, Ghasem
Rahmatpour Rokni2*, Armaghan Kazeminejad2, Hosein
Disease Research Center with Focus on Nosocomial Infection, Bou-Ali Sina
Hospital, Mazandaran University of Medical Sciences, Sari, Iran; 2Mazandaran
University of Medical Sciences, Sari, Iran
Alopecia areata is a non-scarring hair loss, which typically starts quickly.
Atopy is one of the possible predisposing risk factors for this condition.
This study aimed to evaluate the prevalence of thyroid disease, atopic
dermatitis and allergic diseases in children with alopecia areata and
compare the results with healthy individuals.
This case-control study was conducted on 50 patients with alopecia areata,
diagnosed by a dermatologist, and 150 healthy individuals as the control
group. Participants filled the questionnaires, and necessary tests were
In this study, the mean age of the participants was 2.55 ± 14.26 and 3.19 ±
11.92 in the case and control groups, respectively. Prevalence of asthma was
22% in the case group and 12.5% in control group (P = 0.109). Also, allergic
rhinitis and eczema were observed in 20% and 22% of the subjects of the case
group, whereas they were reported to be 8% and 10% in the control group (PV
= 0.03 and 0.175, respectively). Moreover, 28% and 8% of the participants in
the case and control groups had a family history of atopy and allergic
disorders, respectively (P = 0.046). A significant difference was observed
between the two groups regarding gender, type of delivery and contact with
According to the results of this study, a significant association was
observed between the prevalence of alopecia areata and atopic conditions,
such as allergic rhinitis and history of atopic dermatitis.
Citation: Ghaffari J, Rokni GR, Kazeminejad A,
Abedi H. Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis
and Eczema in Children with Alopecia Areata. Open Access Maced J Med Sci.
Keywords: Alopecia areata, Atopic dermatitis, Allergic rhinitis,
*Correspondence: Ghasem Rahmatpour Rokni. Assistant Professor of
Dermatology, Mazandaran University of Medical Sciences, Sari, Iran. E-mail:
Received: 18-Feb-2017; Revised: 29-Apr-2017; Accepted: 03-May-2017;
Online first: 11-Jun-2017
Copyright: © 2017 Javad Ghaffari, Ghasem Rahmatpour Rokni, Armaghan
Kazeminejad, Hosein Abedi. This is an open-access article distributed under
the terms of the Creative Commons Attribution-NonCommercial 4.0
International License (CC BY-NC 4.0).
Funding: This study was supported financially by Research deputy of
Mazandaran University of Medical Sciences.
Competing Interests: Publication of this paper has been supported by
Roche Macedonia DOOEL Skopje.
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- Ghaffari J
- Rokni GR
- Kazeminejad A
- Abedi H