Javad Ghaffari¹, Ghasem Rahmatpour Rokni^2*, Armaghan Kazeminejad², Hosein Abedi²

¹Infectious Disease Research Center with Focus on Nosocomial Infection, Bou-Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran; ²Mazandaran University of Medical Sciences, Sari, Iran

BACKGROUND: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.

AIM: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals.

METHODS: This case-control study was conducted on 50 patients with alopecia areata, diagnosed by a dermatologist, and 150 healthy individuals as the control group. Participants filled the questionnaires, and necessary tests were performed.

RESULTS: In this study, the mean age of the participants was 2.55 ± 14.26 and 3.19 ± 11.92 in the case and control groups, respectively. Prevalence of asthma was 22% in the case group and 12.5% in control group (P = 0.109). Also, allergic rhinitis and eczema were observed in 20% and 22% of the subjects of the case group, whereas they were reported to be 8% and 10% in the control group (PV = 0.03 and 0.175, respectively). Moreover, 28% and 8% of the participants in the case and control groups had a family history of atopy and allergic disorders, respectively (P = 0.046). A significant difference was observed between the two groups regarding gender, type of delivery and contact with animals.

CONCLUSIONS: According to the results of this study, a significant association was observed between the prevalence of alopecia areata and atopic conditions, such as allergic rhinitis and history of atopic dermatitis.

Citation: Ghaffari J, Rokni GR, Kazeminejad A, Abedi H. Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.050
Keywords: Alopecia areata, Atopic dermatitis, Allergic rhinitis, children, asthma.
*Correspondence: Ghasem Rahmatpour Rokni. Assistant Professor of Dermatology, Mazandaran University of Medical Sciences, Sari, Iran. E-mail: Dr.rokni@yahoo.com
Received: 18-Feb-2017; Revised: 29-Apr-2017; Accepted: 03-May-2017; Online first: 11-Jun-2017
Copyright: © 2017 Javad Ghaffari, Ghasem Rahmatpour Rokni, Armaghan Kazeminejad, Hosein Abedi. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This study was supported financially by Research deputy of Mazandaran University of Medical Sciences.
Competing Interests: Publication of this paper has been supported by Roche Macedonia DOOEL Skopje.
 

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