ID Design 2012/DOOEL Skopje, Republic of
Open Access Macedonian Journal of Medical Sciences.
Analysis of Factors that
Influence Hematopoietic Recovery in Autologous Transplanted Patients with
Hematopoietic Stem Cells from Peripheral Blood
Rada M. Grubovic1*, Borce Georgievski2,
Lidija Cevreska2, Sonja Genadieva-Stavric2, Milos R.
1Institute for Transfusion Medicine of RM, Medical Faculty, Ss.
Cyril and Methodius University, Skopje, Republic of Macedonia; 2University
Clinic of Hematology, Medical Faculty, Ss. Cyril and Methodius University,
Skopje, Republic of Macedonia
BACKGROUND: Successful hematopoietic stem cell transplantation (HSCT)
requires a rapid and durable hematopoietic recovery.
AIM: The aim of our study was to analyse factors that influence
hematopoietic recovery after autologous HSCT.
MATERIALS AND METHODS: Multiple regression analysis was used to
analyse factors affecting neutrophil and platelet engraftment in 90
autologous transplanted patients – 30 with acute myeloid leukaemia (AML), 30
with lymphoma and 30 with multiple myeloma (MM) from 2008 till 2016.
RESULTS: The neutrophil recovery in AML patients was significantly
influenced by transfusion support with random-donor platelets, sex and
number of transplanted mononuclear cells (MNC) and CD34+ cells; and in
lymphoma patients, it was influenced by sex, age, mobilisation strategy and
some transplanted MNC. The influence of investigated factors on neutrophil
engraftment in MM patients was not statistically significant. The platelet
recovery in AML patients was influenced by transfusion support with
random-donor platelets; in lymphoma patients, it was influenced by sex, age,
time from diagnosis to harvesting and time from diagnosis to HSCT; and in MM
patients it was influenced by transfusion support with random-donor
CONCLUSION: Additional studies are necessary to better understanding
of engraftment kinetic to improve the safety of HSCT and to minimise
potential complications and expenses related to HSCT.
Citation: Grubovic RM, Georgievski B, Cevreska L,
Genadieva-Stavric S, Grubovic MR. Analysis of Factors that Influence
Hematopoietic Recovery in Autologous Transplanted Patients with
Hematopoietic Stem Cells from Peripheral Blood. Open Access Maced J Med Sci.
Keywords: peripheral blood hematopoietic stem cells; autologous stem
cell transplantation; hematopoietic recovery; engraftment.
*Correspondence: Rada M. Grubovic. Institute for Transfusion Medicine
of RM, Medical Faculty, Ss. Cyril and Methodius University, Skopje. E-mail:
Received: 10-May-2017; Revised: 24-May-2017; Accepted: 25-May-2017; Online
Copyright: © 2017 Rada M. Grubovic, Borce Georgievski, Lidija
Cevreska, Sonja Genadieva-Stavric, Milos R. Grubovic. This is an open-access
article distributed under the terms of the Creative Commons Attribution-NonCommercial
4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: Publication of this paper has been supported by
Roche Macedonia DOOEL Skopje.
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- Grubovic RM
- Georgievski B
- Cevreska L
- Genadieva-Stavric S
- Grubovic MR