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ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.

https://doi.org/10.3889/oamjms.2017.039

eISSN: 1857-9655

Clinical Science

 

 

 

Analysis of Factors that Influence Hematopoietic Recovery in Autologous Transplanted Patients with Hematopoietic Stem Cells from Peripheral Blood


 

Rada M. Grubovic1*, Borce Georgievski2, Lidija Cevreska2, Sonja Genadieva-Stavric2, Milos R. Grubovic1


1Institute for Transfusion Medicine of RM, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia; 2University Clinic of Hematology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

 

Abstract

 

 

BACKGROUND: Successful hematopoietic stem cell transplantation (HSCT) requires a rapid and durable hematopoietic recovery.

AIM: The aim of our study was to analyse factors that influence hematopoietic recovery after autologous HSCT.

MATERIALS AND METHODS: Multiple regression analysis was used to analyse factors affecting neutrophil and platelet engraftment in 90 autologous transplanted patients – 30 with acute myeloid leukaemia (AML), 30 with lymphoma and 30 with multiple myeloma (MM) from 2008 till 2016.

RESULTS: The neutrophil recovery in AML patients was significantly influenced by transfusion support with random-donor platelets, sex and number of transplanted mononuclear cells (MNC) and CD34+ cells; and in lymphoma patients, it was influenced by sex, age, mobilisation strategy and some transplanted MNC. The influence of investigated factors on neutrophil engraftment in MM patients was not statistically significant. The platelet recovery in AML patients was influenced by transfusion support with random-donor platelets; in lymphoma patients, it was influenced by sex, age, time from diagnosis to harvesting and time from diagnosis to HSCT; and in MM patients it was influenced by transfusion support with random-donor platelets.

CONCLUSION: Additional studies are necessary to better understanding of engraftment kinetic to improve the safety of HSCT and to minimise potential complications and expenses related to HSCT.

..................

Citation: Grubovic RM, Georgievski B, Cevreska L, Genadieva-Stavric S, Grubovic MR. Analysis of Factors that Influence Hematopoietic Recovery in Autologous Transplanted Patients with Hematopoietic Stem Cells from Peripheral Blood. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.039
Keywords: peripheral blood hematopoietic stem cells; autologous stem cell transplantation; hematopoietic recovery; engraftment.
*Correspondence: Rada M. Grubovic. Institute for Transfusion Medicine of RM, Medical Faculty, Ss. Cyril and Methodius University, Skopje. E-mail: rgrubovic@yahoo.com
Received: 10-May-2017; Revised: 24-May-2017; Accepted: 25-May-2017; Online first: 03-June-2017
Copyright: 2017 Rada M. Grubovic, Borce Georgievski, Lidija Cevreska, Sonja Genadieva-Stavric, Milos R. Grubovic. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: Publication of this paper has been supported by Roche Macedonia DOOEL Skopje.
 

 

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- Grubovic RM
- Georgievski B
- Cevreska L
- Genadieva-Stavric S
- Grubovic MR


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- Grubovic RM
- Georgievski B
- Cevreska L
- Genadieva-Stavric S
- Grubovic MR

 

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Published by: Id Design 2012/DOOEL Skopje, Republic of Macedonia


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.