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ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.

https://doi.org/10.3889/oamjms.2017.033
eISSN: 1857-9655

Basic Science

 

 

 

Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes


 

Soha M. Abd El Dayem1*, Mona Abd El Kader2, Soheir Ibrahim3, Enas Mokhtar1, Eman Abd El Megeed4


1Pediatrics Department, National Research Centre, Cairo, Egypt; 2Clinical Pathology Department, National Research Centre, Cairo, Egypt; 3Pediatrics Department, Al-Azhar University, Cairo, Egypt; 4Pediatrics Department, Cairo, Egypt

 

Abstract

 

 

AIM: To evaluate leptin and lipid profile in overweight patients with type 1 diabetes.

PATIENTS AND METHODS: The study included 50 overweight patients with type 1 diabetes and 50 age and sex matched healthy controls. Blood samples were taken for evaluation of glycosylated haemoglobin, lipid profile and leptin. Also, urine samples were taken for evaluation of albumin/creatinine ratio.

RESULTS: Leptin level was significantly lower in overweight with type 1 diabetes and showed a significant positive correlation with hip circumference and body mass index and negative correlation with glycosylated haemoglobin (HbA1c). Leptin level was significantly lower in overweight diabetic patients with HbA1c > 7.5 %. The best cut-off point between overweight diabetic group and control group regarding leptin levels was found at 16.9 (ng/ml) with a sensitivity of 68% and specificity of 56%, area under the curve 0.623.

CONCLUSION: Leptin levels were found to be low in overweight patients with type 1 diabetes and showed correlation with the body mass index and hip circumference. LDL was significantly higher while HDL was significantly lower in the diabetic, overweight group indicating increased risk of cardiovascular disease. Leptin level in overweight diabetic patients might be related to the metabolic control.

..................

Citation: Abd El Dayem SM, Abd El Kader M, Ibrahim S, Mokhtar E, Abd El Megeed E. Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.033
Keywords: Leptin; lipid profile; overweight; type 1 diabetic patient.
*Correspondence: Soha Abd El Dayem. Professor of Pediatrics, Consultant of Diabetes and Endocrinology, Medical Research Division, National Research Centre, Pediatrics Department, Cairo, Egypt. Phone: +2 01006716852. E-mail: S_eldayem@yahoo.com
Received: 19-Oct-2016; Revised: 21-Jan-2017; Accepted: 24-Feb-2017; Online first: 19-Mar-2017
Copyright: © 2017 Soha M. Abd El Dayem, Mona Abd El Kader, Soheir Ibrahim, Enas Mokhtar, Eman Abd El Megeed. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing interests exist.
 

 

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Published by: Id Design 2012/DOOEL Skopje, Republic of Macedonia


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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.