ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
https://doi.org/10.3889/oamjms.2017.033
eISSN: 1857-9655
Basic Science
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Leptin and Lipid Profile in
Overweight Patient with Type 1 Diabetes
Soha M. Abd El Dayem1*, Mona Abd El Kader2,
Soheir Ibrahim3, Enas Mokhtar1, Eman Abd El Megeed4
1Pediatrics Department, National Research Centre, Cairo, Egypt;
2Clinical Pathology Department, National Research Centre, Cairo,
Egypt; 3Pediatrics Department, Al-Azhar University, Cairo, Egypt;
4Pediatrics Department, Cairo, Egypt
AIM: To evaluate leptin and lipid profile in overweight patients with
type 1 diabetes.
PATIENTS AND METHODS: The study included 50 overweight patients with
type 1 diabetes and 50 age and sex matched healthy controls. Blood samples
were taken for evaluation of glycosylated haemoglobin, lipid profile and
leptin. Also, urine samples were taken for evaluation of albumin/creatinine
ratio.
RESULTS: Leptin level was significantly lower in overweight with type
1 diabetes and showed a significant positive correlation with hip
circumference and body mass index and negative correlation with glycosylated
haemoglobin (HbA1c). Leptin level was significantly lower in overweight
diabetic patients with HbA1c > 7.5 %. The best cut-off point between
overweight diabetic group and control group regarding leptin levels was
found at 16.9 (ng/ml) with a sensitivity of 68% and specificity of 56%, area
under the curve 0.623.
CONCLUSION: Leptin levels were found to be low in overweight patients
with type 1 diabetes and showed correlation with the body mass index and hip
circumference. LDL was significantly higher while HDL was significantly
lower in the diabetic, overweight group indicating increased risk of
cardiovascular disease. Leptin level in overweight diabetic patients might
be related to the metabolic control.
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Citation: Abd El Dayem SM, Abd El Kader M, Ibrahim
S, Mokhtar E, Abd El Megeed E. Leptin and Lipid Profile in Overweight
Patient with Type 1 Diabetes. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.033
Keywords: Leptin; lipid profile; overweight; type 1 diabetic patient.
*Correspondence: Soha Abd El Dayem. Professor of Pediatrics,
Consultant of Diabetes and Endocrinology, Medical Research Division,
National Research Centre, Pediatrics Department, Cairo, Egypt. Phone: +2
01006716852. E-mail: S_eldayem@yahoo.com
Received: 19-Oct-2016; Revised: 21-Jan-2017; Accepted: 24-Feb-2017; Online
first: 19-Mar-2017
Copyright: © 2017 Soha M. Abd El Dayem, Mona Abd El Kader, Soheir
Ibrahim, Enas Mokhtar, Eman Abd El Megeed. This is an open-access article
distributed under the terms of the Creative Commons Attribution-NonCommercial
4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing
interests exist.
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Abd El Dayem SM
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Abd El Kader M
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Ibrahim S
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Mokhtar E
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Abd El Megeed E
PubMed
- Abd El Dayem SM
- Abd El Kader M
- Ibrahim S
- Mokhtar E
- Abd El Megeed E
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