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ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
https://doi.org/10.3889/oamjms.2017.031
eISSN: 1857-9655
Basic Science
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Serum VEGF Levels in
Helicobacter pylori Infection and Correlation with Helicobacter
pylori cagA and vacA Genes
Gontar Siregar1*, Dina Sari2,
Taufik Sungkar1
1University of Sumatera Utara, Gastroentero-Hepatology, Medan,
Sumatera Utara 20122, Indonesia; 2University of Sumatera Utara,
Nutrition, Medan, Sumatera Utara, Indonesia
BACKGROUND: Helicobacter pylori vacA and cagA genes are
associated with higher virulence. Vascular Endothelial Growth Factor (VEGF)
is one important marker for neo-angiogenesis.
AIM: The purpose of this study was to investigate the relationship
between VEGF serum levels with cagA and vacA genes in H.
pylori infection.
METHODS: A cross-sectional study was done on eighty patients that
consecutive admitted to endoscopy unit. The diagnosis of H. pylori
infection was based on rapid urease test. Serum samples were obtained to
determine circulating VEGF level. Polymerase chain reaction was done to
examine H. pylori vacA and cagA genes. Data analysis were
carried-out using SPSS version 22.
RESULTS: A total of 80 patients were examined. There were 45 (56.3%)
patients infected with Helicobacter pylori. There were 33 (73.3%)
patients with H. pylori cagA positive. Serum VEGF levels in patients
with the H. pylori positive were significantly higher compared to the
patients that have no H. pylori. Serum levels of VEGF were
significantly higher in cagA positive than negative.
CONCLUSION: Serum VEGF level is correlated with H. pylori
infection and its virulence status. The more virulence of H. pylori, cagA
gene, the higher serum VEGF levels were found.
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Citation: Siregar G, Sari D, Sungkar T. Serum VEGF
Levels in Helicobacter pylori Infection and Correlation with Helicobacter
pylori cagA and vacA Genes. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.031
Keywords: Helicobacter pylori; Vascular endothelial growth factor;
cagA gene; vacA gene; Gastritis.
*Correspondence: Gontar Siregar. University of Sumatera Utara,
Gastroentero-Hepatology, Medan, Sumatera Utara 20122, Indonesia. E-mail:
gontarsir@gmail.com
Received: 25-Jan-2017; Revised: 09-Feb-2017; Accepted: 10-Feb-2017; Online
first: 19-Mar-2017
Copyright: © 2017 Gontar Siregar, Dina Sari, Taufik Sungkar. This is
an open-access article distributed under the terms of the Creative Commons
Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing
interests exist.
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