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ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.

https://doi.org/10.3889/oamjms.2017.010
eISSN: 1857-9655

Stomatology

 

 

 

sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease


 

Rajnish K. Singhal1*, Balwant Rai2


1Department of Conservative Dentistry and Endodontics, Maharana Pratap College of Dentistry and Research Centre, Gwalior (M.P), India; 2World Dental Networks, Denmark, Chief, JBR Society, India; Director, KSI, USA

 

Abstract

 

 

BACKGROUND: Different studies have implicated the exposure to systemic conditions in the aetiology of cardiovascular diseases like chronic inflammation including chronic periodontitis.

AIM: The present study has been conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic marker of inflammation and has been identified as risk factors for cardiovascular diseases.

MATERIAL AND METHODS: sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged 20-45 years and in 20 control patients without periodontitis (M:F::10:10, aged 20-48 years). Measurement of sTNF-R1 and sTNF-R2 was carried out in duplicate with standardised, commercially available enzyme immunoassays (R&D Systems Europe, Abingdon, UK).

RESULTS: The mean sTNF-R1 and sTNF-R2 levels in periodontitis were 820 (240) pg/ml (413 – 1620 pg/ml) and 1309 (403) pg/ml (540 – 2430 pg/ml), while in normal sTNF-R1 and sTNF – R2 levels were 740 (340) pg/ml (407-1240 pg/ml) and 1283 (414) pg (480 – 2340 pg/ml) respectively. Results indicated a positive high relationship between cardiovascular markers such as sTNF-R1 and sTNF – R2 and apical periodontitis.

CONCLUSION: Elevated levels of sTNF-R1 and sTNF – R2 in apical periodontitis patients indicate an increased independent risk of coronary heart disease.
 

..................

Citation: Singhal RK, Rai B. sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.010
Keywords: sTNF-R; Apical Periodontitis; Systemic inflammatory; coronary heart disease.
*Correspondence: Dr. Rajnish K Singhal, MDS. Prof. and Head, Dept of Conservative Dentistry and Endodontics, Maharana Pratap College of Dentistry and Research Centre, Gwalior (M.P), India. E-mail: rajnishksinghal@gmail.com
Received: 27-Nov-2016; Revised: 28-Dec-2016; Accepted: 29-Dec-2016; Online first: 17-Jan-2017
Copyright: © 2017 Rajnish K. Singhal, Balwant Rai.   This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing interests exist.

 

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Published by: Id Design 2012/DOOEL Skopje, Republic of Macedonia


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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.