ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
https://doi.org/10.3889/oamjms.2017.010
eISSN: 1857-9655
Stomatology
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sTNF-R Levels: Apical
Periodontitis Linked to Coronary Heart Disease
Rajnish K. Singhal1*, Balwant Rai2
1Department of Conservative Dentistry and Endodontics, Maharana
Pratap College of Dentistry and Research Centre, Gwalior (M.P), India;
2World Dental Networks, Denmark, Chief, JBR Society, India; Director,
KSI, USA
BACKGROUND: Different studies have implicated the exposure to
systemic conditions in the aetiology of cardiovascular diseases like chronic
inflammation including chronic periodontitis.
AIM: The present study has been conducted to examine whether
biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a
systemic marker of inflammation and has been identified as risk factors for
cardiovascular diseases.
MATERIAL AND METHODS: sTNF-R levels were measured in 52 patients with
apical periodontitis (M:F::25:27), aged 20-45 years and in 20 control
patients without periodontitis (M:F::10:10, aged 20-48 years). Measurement
of sTNF-R1 and sTNF-R2 was carried out in duplicate with standardised,
commercially available enzyme immunoassays (R&D Systems Europe, Abingdon,
UK).
RESULTS: The mean sTNF-R1 and sTNF-R2 levels in periodontitis were
820 (240) pg/ml (413 – 1620 pg/ml) and 1309 (403) pg/ml (540 – 2430 pg/ml),
while in normal sTNF-R1 and sTNF – R2 levels were 740 (340) pg/ml (407-1240
pg/ml) and 1283 (414) pg (480 – 2340 pg/ml) respectively. Results indicated
a positive high relationship between cardiovascular markers such as sTNF-R1
and sTNF – R2 and apical periodontitis.
CONCLUSION: Elevated levels of sTNF-R1 and sTNF – R2 in apical
periodontitis patients indicate an increased independent risk of coronary
heart disease.
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Citation: Singhal RK, Rai B. sTNF-R Levels: Apical
Periodontitis Linked to Coronary Heart Disease. Open Access Maced J Med Sci.
https://doi.org/10.3889/oamjms.2017.010
Keywords: sTNF-R; Apical Periodontitis; Systemic inflammatory;
coronary heart disease.
*Correspondence: Dr. Rajnish K Singhal, MDS. Prof. and Head, Dept of
Conservative Dentistry and Endodontics, Maharana Pratap College of Dentistry
and Research Centre, Gwalior (M.P), India. E-mail: rajnishksinghal@gmail.com
Received: 27-Nov-2016; Revised: 28-Dec-2016; Accepted: 29-Dec-2016; Online
first: 17-Jan-2017
Copyright: © 2017 Rajnish K. Singhal, Balwant Rai. This is an open-access
article distributed under the terms of the Creative Commons Attribution-NonCommercial
4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing
interests exist.
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