Nour El Hoda S. Ismael¹, Samar A. El Sheikh¹, Suzan M. Talaat^2*, Eman M. Salem²

¹Faculty of Medicine, Cairo University, Cairo, Egypt; ²Ahmed Maher Teaching Hospital, Cairo, Egypt

BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers worldwide. Microsatellite instability (MSI) is detected in about 15% of all colorectal cancers. CRC with MSI has particular characteristics such as improved survival rates and better prognosis. They also have a distinct sensitivity to the action of chemotherapy.

AIM: The aim of the study was to detect microsatellite instability in a cohort of colorectal cancer Egyptian patients using the immunohistochemical expression of mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2).

MATERIAL AND METHODS: Cases were divided into Microsatellite stable (MSS), Microsatellite unstable low (MSI-L) and Microsatellite unstable high (MSI-H). This Microsatellite stability status was correlated with different clinicopathological parameters.

RESULTS: There was a statistically significant correlation between the age of cases, tumor site & grade and the microsatellite stability status. There was no statistically significant correlation between the gender of patients, tumor subtype, stage, mucoid change, necrosis, tumor borders, lymphocytic response, lymphovascular emboli and the microsatellite stability status.

Citation: Ismael NEHS, El Sheikh SA, Talaat SM, Salem EM. Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2017.003
Keywords: Colorectal cancer; Immunohistochemistry; Lynch Syndrome; Microsatellite instability; Mismatch repair proteins.
*Correspondence: Suzan M. Talaat. Ahmed Maher Teaching Hospital, Cairo, Egypt. E-mail: suzabella0000@gmail.com
Received: 29-Dec-2016; Revised: 01-Feb-2017; Accepted: 03-Feb-2017; Online first: 12-Feb-2017
Copyright: © 2017 Nour El Hoda S. Ismael, Samar A. El Sheikh, Suzan M. Talaat, Eman M. Salem.  This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing interests exist.
 

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