ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.134
eISSN: 1857-9655
Basic Science
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The Hidden Function of Vitamin D
Hiba Sibaii1*, Salwa Refat El-Zayat1,
Azza Abd El-Shaheed2, Nermine N. Mahfouz2, Sara F.
Sallam2, Marwa H. El Azma1
1Medical Physiology Department, National Research Centre, Medical
Division, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt; 2Child
Health Department, National Research Centre, Medical Division, 33 El-Bohouth
Street, Dokki, POB:12311, Cairo, Egypt
AIM: There are no reports regarding the influence of vitamin D on
thymosin ß4 and the cluster of differentiation CD4 levels which are
important for maintaining a healthy immune system. Consequently, we aimed to
explore this relationship through a study.
MATERIAL AND METHODS: The study was carried out on 35 subjects,
screened for 25-hydroxy vitamin D[25 (OH) D] using ELISA method and they
were divided into two groups: Group 1 consists of 10 healthy subjects with
sufficient vit. D level > 24.8 ng/ml. Group 2 consists of 25 subjects
suffering, severely, from vitamin D deficiency at level < 11.325 ng/ml.
Also, Thymosin ß4, CD4 and zinc levels were performed.
RESULTS: There were significant differences between the two groups in
the concentration levels of thymosin β4, as the group 1 has shown higher
levels (P = 0.005). Whereas, CD4 and zinc levels didn’t show any significant
difference between the two groups. At the same time, a significant positive
correlation has been observed between vitamin D, thymosin β4, and CD4 at (r
= 0.719; P = 0.001), and (r = 0.559, P = 0.001) respectively.
CONCLUSION: We concluded that vitamin D may be an essential factor
that influence or determine the level of thymosin β4. This study is the
first that focused on demonstrating that sufficient level of vitamin D may
have the ability to influence the thymic hormone thymosin β4 levels. Further
studies on large scale of subjects are needed to explore the positive
correlation we had found between vitamin D and thymosin β4 and CD4.
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Citation: Sibaii H, El-Zayat SR, El-Shaheed AA,
Mahfouz NN, Sallam SF, El Azma MH. The Hidden Function of Vitamin D. Open
Access Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.134
Keywords: Vitamin D; thymosin beta-4; immunity.
*Correspondence: Hiba Sibaii. Medical Physiology Department, National
Research Centre, Medical Division, 33 El-Bohouth Street, Dokki, POB:12311,
Cairo, Egypt. E-mail: hrs992002@yahoo.com
Received: 10-Oct-2016; Revised: 10-Nov-2016; Accepted: 11-Nov-2016; Online
first: 30-Nov-2016
Copyright: © 2016 Hiba Sibaii, Salwa Refat El-Zayat, Azza Abd El-Shaheed,
Nermine N. Mahfouz, Sara F. Sallam, Marwa H. El Azma. This is an open-access
article distributed under the terms of the Creative Commons Attribution-NonCommercial
4.0 International License (CC
BY-NC 4.0).
Funding: Research project was funded by the University Program
coordinated by the Coordinator of Research and Graduate Studies Stricto
Sensu, Brazil.
Competing Interests: The authors have declared that no competing
interests exist.
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