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ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2016.134
eISSN: 1857-9655

Basic Science

 

 

 

The Hidden Function of Vitamin D


 

Hiba Sibaii1*, Salwa Refat El-Zayat1, Azza Abd El-Shaheed2, Nermine N. Mahfouz2, Sara F. Sallam2, Marwa H. El Azma1


1Medical Physiology Department, National Research Centre, Medical Division, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt; 2Child Health Department, National Research Centre, Medical Division, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt

 

Abstract

 

 

AIM: There are no reports regarding the influence of vitamin D on thymosin ß4 and the cluster of differentiation CD4 levels which are important for maintaining a healthy immune system. Consequently, we aimed to explore this relationship through a study.

MATERIAL AND METHODS: The study was carried out on 35 subjects, screened for 25-hydroxy vitamin D[25 (OH) D] using ELISA method and they were divided into two groups: Group 1 consists of 10 healthy subjects with sufficient vit. D level > 24.8 ng/ml. Group 2 consists of 25 subjects suffering, severely, from vitamin D deficiency at level < 11.325 ng/ml. Also, Thymosin ß4, CD4 and zinc levels were performed.

RESULTS: There were significant differences between the two groups in the concentration levels of thymosin β4, as the group 1 has shown higher levels (P = 0.005). Whereas, CD4 and zinc levels didn’t show any significant difference between the two groups. At the same time, a significant positive correlation has been observed between vitamin D, thymosin β4, and CD4 at (r = 0.719; P = 0.001), and (r = 0.559, P = 0.001) respectively.

CONCLUSION: We concluded that vitamin D may be an essential factor that influence or determine the level of thymosin β4. This study is the first that focused on demonstrating that sufficient level of vitamin D may have the ability to influence the thymic hormone thymosin β4 levels. Further studies on large scale of subjects are needed to explore the positive correlation we had found between vitamin D and thymosin β4 and CD4.

..................

Citation: Sibaii H, El-Zayat SR, El-Shaheed AA, Mahfouz NN, Sallam SF, El Azma MH. The Hidden Function of Vitamin D. Open Access Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.134
Keywords: Vitamin D; thymosin beta-4; immunity.
*Correspondence: Hiba Sibaii. Medical Physiology Department, National Research Centre, Medical Division, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt. E-mail: hrs992002@yahoo.com
Received: 10-Oct-2016; Revised: 10-Nov-2016; Accepted: 11-Nov-2016; Online first: 30-Nov-2016
Copyright: © 2016 Hiba Sibaii, Salwa Refat El-Zayat, Azza Abd El-Shaheed, Nermine N. Mahfouz, Sara F. Sallam, Marwa H. El Azma. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Funding: Research project was funded by the University Program coordinated by the Coordinator of Research and Graduate Studies Stricto Sensu, Brazil.
Competing Interests: The authors have declared that no competing interests exist.

 

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- Sibaii H
- El-Zayat SR
- El-Shaheed AA
- Mahfouz NN
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- El Azma MH


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- Sibaii H
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- El-Shaheed AA
- Mahfouz NN
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Published by: ID Design Press, part of the ID Design 2012/DOOEL Skopje, Republic of Macedonia


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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.