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ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.114
eISSN: 1857-9655
Basic Science
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Vascular Genetic Variants and
Ischemic Stroke Susceptibility in Albanians from the Republic of Macedonia
Bajram Kamberi¹*, Farije Kamberi², Mirko Spiroski³
¹Neurological Department, Clinical Hospital, Tetovo, Republic of Macedonia;
²School Medical Centre, “Nikolla Shtejn” Tetovo, Republic of Macedonia;
³Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss
Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia
BACKGROUND: Acute first-ever ischemic stroke (FIS) is a
heterogeneous, polygenic disorder. The contribution of vascular genetic
variants as inherited causes of ischemic stroke has remained controversial.
AIM: To examine the association of genetic variants in vascular
factors with the occurrence of FIS.
MATERIAL AND METHODS: The current research was performed in a group
of 39 patients with FIS (study group) and 102 healthy volunteers (control
group). We analyzed the prevalence of vascular genetic variants in following
genes: factor V, prothrombin, methylenetetrahydrofolate reductase (MTHFR),
factor XIII, plasminogen activator 1, endothelial protein C receptor (EPCR),
apolipoprotein B, apolipoprotein E, β-fibrinogen, human platelet antigen 1,
angiotensin-converting enzyme (ACE), endothelial nitric oxide synthase (eNOS)
and lymphotoxin alpha.
RESULTS: It was found that heterozygous LTA 804C>A and
FXIII V34L Leu/Leu were significantly more frequent in patients with FIS
than in control group (p = 0.036 and p = 0.017, respectively). The frequency
of FXIII V34L Val/Val was significantly lower in patients with FIS
than in control group (p = 0.020). Other frequencies of vascular gene
variants in patients with FIS and in control group were not significantly
different.
CONCLUSIONS: This is the first comprehensive study to present data
indicating that polymorphism of vascular genes in the prevalence of acute
FIS exists in the Albanian population from the Republic of Macedonia.
Variations in these genes have been detected in patients with acute FIS,
suggesting that their combination might act in a susceptible or protective
manner in this Albanian population.
..................
Citation: Kamberi B, Kamberi F, Spiroski M.
Vascular Genetic Variants and Ischemic Stroke Susceptibility in Albanians
from the Republic of Macedonia. Open Access Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.114
Keywords: ischemic stroke; vascular genetic variations; association;
Albanians; Republic of Macedonia.
*Correspondence: Bajram Kamberi, MD, PhD. Department of Neurology,
Clinical Hospital Tetovo, 1200 Tetovo, Republic of Macedonia. Tel: (+389 44)
72 239 014, E-mail: bajram-kamberi@yahoo.com
Received: 01-Jul-2016; Revised: 26-Sep-2016; Accepted: 28-Sep-2016; Online
first: 01-Oct-2016
Copyright: © 2016 Bajram Kamberi, Farije Kamberi, Mirko Spiroski.
This is an open-access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Funding: This research is part of the project "Gene mutations
associated with diseases of blood vessels in the Republic of Macedonia",
supported by the Ministry of Education and Science from the Republic of
Macedonia (to Spiroski M, No 13-3589/1, 26.07.2010).
Competing Interests: The authors have declared that no competing
interests exist.
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