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ID Design 2012/DOOEL Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2016.110
eISSN: 1857-9655

Basic Science

 

 

 

Assessment of the −174G/C (rs1800795) and −572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis


 

Khalda Amr1, Rehab El-Awady2*, Hala Raslan1


1National Research Center, Internal Medicine, Cairo, Egypt; 2Al-Azhar University Faculty of Pharmacy, Biochemistry, Cairo, Egypt

 

Abstract

 

 

AIM: This study aimed to investigate genotype and allele frequencies of −174 (rs1800795) and −572 (rs1800796) IL-6 promoter gene polymorphisms in Egyptian patients with rheumatoid arthritis (RA) in comparison to control group.

METHODS: The study was conducted on 198 Egyptian subjects (99 RA patients and 99 healthy control).The promoter region of the IL-6 gene was amplified by PCR using DNAs from patients and the controls, and their PCR products were digested by suitable enzymes.

RESULTS: No statistical differences were found in −572G/C genotype (P = 0.177) or allele (P = 0.147) frequencies between RA patients and controls. Significant differences were observed in −174G/C genotype (P ˂ 0.001) and allele (P ˂ 0.001) frequencies between RA patients and controls.

CONCLUSION: A significant association of IL-6 −174G/C gene polymorphism and RA in Egyptian population was found with significantly higher frequencies of GC and CC genotypes and C allele in RA patients compared to controls. No association was found between IL-6 −572G/C gene polymorphism and RA.

..................

Citation: Amr K, El-Awady R, Raslan H. Assessment of the −174G/C (rs1800795) and −572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis. Open Access Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.110
Keywords: Rheumatoid arthritis; Interleukin 6; IL6–174G/C, IL6–572G/C; gene polymorphism.
*Correspondence: Rehab El-Awady. Al-Azhar University Faculty of Pharmacy, Biochemistry, Cairo, Egypt. E-mail: r.awady@yahoo.com
Received: 06-Aug-2016; Revised: 21-Sep-2016; Accepted: 22-Sep-2016; Online first: 11-Oct-2016
Copyright: © 2016 Khalda Amr, Rehab El-Awady, Hala Raslan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing interests exist.

 

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Published by: Id Design 2012/DOOEL Skopje, Republic of Macedonia


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