ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.110
eISSN: 1857-9655
Basic Science
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Assessment of the −174G/C
(rs1800795) and −572G/C (rs1800796) Interleukin 6 Gene
Polymorphisms in Egyptian Patients with Rheumatoid Arthritis
Khalda Amr1, Rehab El-Awady2*, Hala
Raslan1
1National Research Center, Internal Medicine, Cairo, Egypt;
2Al-Azhar University Faculty of Pharmacy, Biochemistry, Cairo, Egypt
AIM: This study aimed to investigate genotype and allele frequencies
of −174 (rs1800795) and −572 (rs1800796) IL-6 promoter
gene polymorphisms in Egyptian patients with rheumatoid arthritis (RA) in
comparison to control group.
METHODS: The study was conducted on 198 Egyptian subjects (99 RA
patients and 99 healthy control).The promoter region of the IL-6 gene was
amplified by PCR using DNAs from patients and the controls, and their PCR
products were digested by suitable enzymes.
RESULTS: No statistical differences were found in −572G/C
genotype (P = 0.177) or allele (P = 0.147) frequencies between RA patients
and controls. Significant differences were observed in −174G/C
genotype (P ˂ 0.001) and allele (P ˂ 0.001) frequencies between RA patients
and controls.
CONCLUSION: A significant association of IL-6 −174G/C gene
polymorphism and RA in Egyptian population was found with significantly
higher frequencies of GC and CC genotypes and C allele in RA patients
compared to controls. No association was found between IL-6 −572G/C
gene polymorphism and RA.
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Citation: Amr K, El-Awady R, Raslan H. Assessment
of the −174G/C (rs1800795) and −572G/C (rs1800796)
Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid
Arthritis. Open Access Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.110
Keywords: Rheumatoid arthritis; Interleukin 6; IL6–174G/C,
IL6–572G/C; gene polymorphism.
*Correspondence: Rehab El-Awady. Al-Azhar University Faculty of
Pharmacy, Biochemistry, Cairo, Egypt. E-mail: r.awady@yahoo.com
Received: 06-Aug-2016; Revised: 21-Sep-2016; Accepted: 22-Sep-2016; Online
first: 11-Oct-2016
Copyright: © 2016 Khalda Amr, Rehab El-Awady, Hala Raslan. This is an
open-access article distributed under the terms of the Creative Commons
Attribution License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original author and source are
credited.
Funding: This research did not receive any financial support.
Competing Interests: The authors have declared that no competing
interests exist.
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