ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.086
eISSN: 1857-9655
Review Article
|
|
Etiopathogenesis of
Differentiated Thyroid Carcinomas
Tanja Makazlieva*, Olivija Vaskova, Venjamin
Majstorov
Institute of Pathophysiology and Nuclear Medicine "Akademik Isak Tadzer",
Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje,
Republic of Macedonia
INTRODUCTION: Thyroid malignomas are a heterogeneous group of
neoplasm consisting of most frequent differentiated encountered carcinomas,
papillary and follicular thyroid carcinoma, then medullary thyroid carcinoma
originating from neuroendocrine calcitonin-producing C-cells and rare forms
of thyroid lymphomas arising from intrathyroidal lymphatic tissue, thyroid
sarcomas and poorly differentiated anaplastic thyroid carcinoma. There are
increasing numbers of epidemiological studies and publications that have
suggested increased incidence rate of thyroid carcinomas. We have read,
analysed and compare available reviews and original articles investigating
different etiological factors in the development of thyroid carcinomas
through Google Scholar and PubMed Database.
DISCUSSION: Aetiology involved in the development of thyroid
carcinomas is multifactorial and includes external influences, as well as
constitutional predispositions and genetic etiological factors. The actual
effect of environmental and constitutional factors is on promoting genetic
and epigenetic alterations which result in cell proliferation and
oncogenesis. Until now are identified numerous genetic alterations, assumed
to have an important role in oncogenesis, with MAPK and PI3K-AKT as crucial
signalling networks regulating growth, proliferation, differentiation and
cell survival/apoptosis.
CONCLUSION: This new molecular insight could have a crucial impact on
diagnosis and also on improving and selecting an appropriate treatment to
the patients with thyroid malignancies.
..................
Citation: Makazlieva T, Vaskova O, Majstorov V.
Etiopathogenesis of Differentiated Thyroid Carcinomas. Open Access Maced J
Med Sci. http://dx.doi.org/10.3889/oamjms.2016.086
Keywords: Papillary thyroid carcinoma; Follicular thyroid carcinoma;
radiation exposure; MAPK signalling network; PI3K-AKT pathway.
*Correspondence: Tanja Makazlieva. Institute of Pathophysiology and
Nuclear Medicine "Akademik Isak Tadzer", Medical Faculty, Ss Cyril and
Methodius University of Skopje, Skopje, Republic of Macedonia. E- mail:
tmakazlieva@gmail.com
Received: 20-Jun-2016; Revised: 20-Jul-2016; Accepted: 22-Jul-2016; Online
first: 02-Aug-2016
Copyright: © 2016 Tanja Makazlieva, Olivija Vaskova, Venjamin
Majstorov.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
|
<
Previous
|
Next Article >
Table of contents
This Article
(free)
Full text (pdf)
Full text OnlineFirst (pdf)
Google Scholar
-
Makazlieva T
-
Vaskova O
-
Majstorov V
PubMed
- Makazlieva T
- Vaskova O
- Majstorov V
|