ID Design 2012/DOOEL Skopje, Republic of
Macedonia
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.073
eISSN: 1857-9655
Case Report
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Two Pregnancies with a Different
Outcome in a Patient with Alport Syndrome
Biljana Gerasimovska Kitanovska1*, Vesna
Gerasimovska1, Vesna Livrinova2
1University Clinic of Nephrology, Ss Cyril and Methodius
University of Skopje, Skopje, Republic of Macedonia; 2University
Clinic of Gynecology and Obstetrics, Ss Cyril and Methodius University of
Skopje, Skopje, Republic of Macedonia
BACKGROUND: Alport syndrome is a genetic disease that progresses to
chronic kidney failure, with X-linked, autosomal dominant or autosomal
recessive type of inheritance. Women are generally carriers of the mutation
and have a milder form of the disease. During pregnancy, they have an
increased risk of impaired kidney function and preeclampsia.
CASE PRESENTATION: A 27-year old woman, gravida 1, para 0, in her
23rd gestational week came to the outpatient unit of the University Clinic
of Nephrology for the first time because of slowly progressing proteinuria
and Alport syndrome. She was admitted to the gynaecological ward in her 29th
gw for proteinuria which increased from 3.8 g/day up to 20 g/day and the
serum creatinine increased to 120- 150 micromol/l. She was delivered in the
30th gestational week due to obstetrical indications with a cesarian section
and delivered a baby with a birth weight of 880 g. After delivery,
proteinuria decreased to 2 g/d within 2 months and an angiotensin-converting
enzyme inhibitor (ACEI) was started. Her second pregnancy, after 2 years,
had an uneventful course and she delivered a healthy baby weighing 3000 g in
the 39th week. Six months after the second delivery, her renal function
remained normal and her proteinuria was 2 g/d.
CONCLUSIONS: Pre-pregnancy counselling and frequent controls during
pregnancy are necessary for women with Alport syndrome, as well as regular
monitoring after delivery. Recent reports are more in favour of good
pregnancy and nephrological outcomes in women with Alport syndrome when
renal disease is not advanced.
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Citation: Gerasimovska Kitanovska B, Gerasimovska
V, Livrinova V. Two Pregnancies with a Different Outcome in a Patient with
Alport Syndrome. Open Access Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.073
Keywords: Alport syndrome; chronic kidney disease; pregnancy.
*Correspondence: Assoc. Prof. Biljana Gerasimovska Kitanovska. Clinic
of Nephrology, Medical Faculty, Vodnjanska 17, Skopje 1000, Republic of
Macedonia. E-mail: bgerasimovska@yahoo.com
Received: 07-Jun-2016; Revised: 24-Jun-2016; Accepted: 25-Jun-2016; Online
first: 02-Jul-2016
Copyright: © 2016 Biljana Gerasimovska Kitanovska, Vesna Gerasimovska,
Vesna Livrinova.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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