Mariya Angelova^1*, Ivan Todorov¹, Emil Kovachev²

¹Department of Obstetrics and Gynecology, Trakia University, Faculty of Medicine, Stara Zagora, Bulgaria; ²Department of Obstetrics and Gynecology, Paraskev Stoyanov Medical University, Varna, Bulgaria

AIM: To determine the prognostic value of the low Pregnancy-associated plasma protein A (PAPP-A) levels in the early stages of pregnancy (11–13 weeks GA) independently and in combination with a Doppler test of the uterine arteries during the second half of pregnancy (22–23 weeks GA).

MATERIAL AND METHODS: The study covered the period 2010–2011 and included 106 pregnant women, aged 35–40, with a single child pregnancy. The research excluded pregnant women with anomalies of the fetus, smokers and women taking prophylactically low doses of aspirin.

RESULTS: Thirty-six pregnant women had PAPP-A level below 0.4 MoM, whereas 20 of them developed preeclampsia and 7 – early preeclampsia. The combination of the low PAPP-A values and the abnormal Doppler test of the uterine arteries is with a considerably better prognostic value in regards to the risk of developing preeclampsia.

CONCLUSION: The Doppler test is a non-invasive, quick and easy method for assessment of the uterine-placental blood flow.
 

Citation: Angelova M, Todorov I, Kovachev E. Early Prognostic Factors for the Progress of Preeclampsia – Our Experience in the Period 2010-2011. Open Access Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.065
Keywords: Preeclampsia; Doppler test; Pregnancy-associated plasma protein A; Body Mass Index.
*Correspondence: Mariya Angelova. Department of Obstetrics and Gynecology, Trakia University, Faculty of Medicine, Stara Zagora, Bulgaria. E-mail: angelova70@abv.bg
Received: 27-Apr-2016; Revised: 20-May-2016; Accepted: 25-May-2016; Online first: 06-Aug-2016
Copyright: © 2016 Mariya Angelova, Ivan Todorov, Emil Kovachev. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.

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