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Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.037
eISSN: 1857-9655
Clinical Science
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Metabolic Syndrome and
Cardiovascular Risk Factors in Obese Adolescent
Manal Mansour1*, Yasser E. Nassef1,
Mones Abu Shady1, Ali Abdel Aziz1, Heba A. El Malt2
1Child Health Department, National Research Center, Cairo, Egypt;
2Biochemistry Department, National Research Center, Cairo, Egypt
BACKGROUND: Childhood and adolescent obesity is associated with
insulin resistance, abnormal glucose metabolism, hypertension, dyslipidemia,
inflammation, liver disease, and compromised vascular function. The purpose
of this study was to determine the prevalence of cardiovascular risk factor
abnormalities and metabolic syndrome in a sample of obese adolescent as
prevalence data might be helpful in improving engagement with obesity
treatment in future. The high blood lipid levels and obesity are the main
risk factors for cardio vascular diseases. Atherosclerotic process begins in
childhood.
AIM: This study aimed to investigate the relationship between obesity
in adolescent and their blood lipids levels and blood glucose level.
METHODS: This study was conducted with 100 adolescents of both gender
age 12-17 years and body mass index (BMI) greater than 95th percentiles and
100 normal adolescents as control group. The blood samples were collected
from all adolescents after overnight fasting (10 hours) to analyze blood
lipids (Total cholesterol, high density lipoprotein, low density
lipoprotein) and hematological profile (Hemoglobin, platelets and red blood
cell, C reactive protein and fasting blood glucose.
RESULTS: There were statistical difference between the two groups for
red blood cells (P<0.001), Hemoglobin (P < 0.001) and platelets (P = 0.002),
CRP (P = 0.02). Positive correlation was found between the two groups as
regards total cholesterol (P = 0.0001), P value was positive for HDL (P =
0.005 and Atherogenic index P value was positive (P = 0.002). Positive
correlation was found between the two group as regards fasting blood glucose
(P = 0.001).
CONCLUSION: Saturated fat was associated with elevated lipid levels
in obese children. These results reinforce the importance of healthy dietary
habits since child-hood in order to reduce the risks of cardiovascular
diseases in adulthood.
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Citation: Mansour M, Nassef YE, Abu Shady M, Azziz
AA, El Malt HA. Metabolic Syndrome and Cardiovascular Risk Factors in Obese
Adolescent. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.025
Key words: cholesterol; cardiovascular diseases; body mass index;
Blood glucose level; C-reactive protein.
*Correspondence: Dr. Manal Mansour Salem. Child Health Department,
National Research Center, Egypt. E-mail: mnlsalem@hotmail.com
Received: 08-Jan-2016; Revised: 24-Jan-2016; Accepted: 25-Jan-2016; Online
first: 02-Mar-2016
Copyright: © 2016 Manal Mansour, Yasser E. Nassef, Mones ABU Shady,
Ali Abdel Aziz, Heba A. El Malt.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Mansour M
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Nassef YE
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Abu Shady M
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Aziz AA
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El Malt HA
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- Mansour M
- Nassef YE
- Abu Shady M
- Aziz AA
- El Malt HA
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