ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.032
eISSN: 1857-9655
Basic Science
|
|
Immunomodulatory Effect of H.
Pylori CagA Genotype and Gastric Hormones On Gastric Versus Inflammatory
Cells Fas Gene Expression in Iraqi Patients with Gastroduodenal Disorders
Ali Ibrahim Ali AL-Ezzy*
Department of Pathology, College of Veterinary Medicine, Diyala University,
Baquba, Diyala Province, Iraq
AIM: To evaluate the Immunomodulatory effects of CagA
expression; pepsinogen I, II & gastrin-17 on PMNs and lymphocytes Fas
expression in inflammatory and gastric cells; demographic distribution of
Fas molecule in gastric tissue and inflammatory cells.
METHODS: Gastroduodenal biopsies were taken from 80 patients for
histopathology and H. pylori diagnosis. Serum samples were used for
evaluation of pepsinogen I (PGI); (PGII); gastrin-17 (G-17).
RESULTS: Significant difference (p < 0.001) in lymphocytes & PMNs Fas
expression; epithelial & lamina propria Fas localization among H. pylori
associated gastric disorders. No correlation between grade of lymphocytes &
PMNs Fas expression in gastric epithelia; lamina propria and types of
gastric disorder. Significant difference (p < 0.001) in total gastric Fas
expression, epithelial Fas; lamina propria and gastric gland Fas expression
according to CagA, PGI; PGII; PGI/PGII; Gastrin-17. Total gastric Fas
expression has significant correlation with CagA, PGII levels.
Gastric epithelial and gastric lamina propria Fas expression have
significant correlation with CagA, PGI; PGII levels. Significant
difference (p < 0.001) was found in lymphocytes & PMNs Fas expression;
epithelial & lamina propria localization of lymphocytes & PMNs Fas
expression according to CagA, PGI; PGII; PGI/PGII; Gastrin-17.
Lymphocytes Fas expression have correlation with PGI, PGII, PGI/PGII. PMNs
Fas expression have correlation with PGI, PGII.
CONCLUSION: Fas gene expression and localization on gastric and
inflammatory cells affected directly by H. pylori CagA and indirectly
by gastric hormones. This contributes to progression of various gastric
disorders according to severity of CagA induced gastric pathology and
gastric hormones disturbance throughout the course of infection and disease.
..................
Citation: AL-Ezzy AIA. Immunomodulatory Effect of
H. Pylori CagA Genotype and Gastric Hormones On Gastric Versus Inflammatory
Cells Fas Gene Expression in Iraqi Patients with Gastroduodenal Disorders.
OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.032
Key words: Fas gene; gastric disorders; pepsinogens; gastrin -17; H.
pylori, CagA.
*Correspondence: Ali Ibrahim Ali Al-Ezzy. Department of Pathology,
College of Veterinary Medicine, Diyala University, Baquba, Diyala Province,
Iraq. E-mail: alizziibrahim@gmail.com
Received: 23-Jan-2016; Revised: 19-Feb-2016; Accepted: 20-Feb-2016; Online
first: 15-Mar-2016
Copyright: © 2016 Ali Ibrahim Ali AL-Ezzy.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
|
<
Previous
|
Next Article >
Table of contents
This Article
(free)
Full text (pdf)
Full text OnlineFirst (pdf)
Google Scholar
-
AL-Ezzy AIA
PubMed
- AL-Ezzy AIA
|