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ID Design 2012/DOOEL Skopje

Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2016.032
eISSN: 1857-9655

Basic Science

 

 

Immunomodulatory Effect of H. Pylori CagA Genotype and Gastric Hormones On Gastric Versus Inflammatory Cells Fas Gene Expression in Iraqi Patients with Gastroduodenal Disorders


 

Ali Ibrahim Ali AL-Ezzy*

Department of Pathology, College of Veterinary Medicine, Diyala University, Baquba, Diyala Province, Iraq

 

Abstract

 

 

AIM: To evaluate the Immunomodulatory effects of CagA expression; pepsinogen I, II & gastrin-17 on PMNs and lymphocytes Fas expression in inflammatory and gastric cells; demographic distribution of Fas molecule in gastric tissue and inflammatory cells.

METHODS: Gastroduodenal biopsies were taken from 80 patients for histopathology and H. pylori diagnosis. Serum samples were used for evaluation of pepsinogen I (PGI); (PGII); gastrin-17 (G-17).

RESULTS: Significant difference (p < 0.001) in lymphocytes & PMNs Fas expression; epithelial & lamina propria Fas localization among H. pylori associated gastric disorders. No correlation between grade of lymphocytes & PMNs Fas expression in gastric epithelia; lamina propria and types of gastric disorder. Significant difference (p < 0.001) in total gastric Fas expression, epithelial Fas; lamina propria and gastric gland Fas expression according to CagA, PGI; PGII; PGI/PGII; Gastrin-17. Total gastric Fas expression has significant correlation with CagA, PGII levels. Gastric epithelial and gastric lamina propria Fas expression have significant correlation with CagA, PGI; PGII levels. Significant difference (p < 0.001) was found in lymphocytes & PMNs Fas expression; epithelial & lamina propria localization of lymphocytes & PMNs Fas expression according to CagA, PGI; PGII; PGI/PGII; Gastrin-17. Lymphocytes Fas expression have correlation with PGI, PGII, PGI/PGII. PMNs Fas expression have correlation with PGI, PGII.

CONCLUSION: Fas gene expression and localization on gastric and inflammatory cells affected directly by H. pylori CagA and indirectly by gastric hormones. This contributes to progression of various gastric disorders according to severity of CagA induced gastric pathology and gastric hormones disturbance throughout the course of infection and disease.
 

..................

Citation: AL-Ezzy AIA. Immunomodulatory Effect of H. Pylori CagA Genotype and Gastric Hormones On Gastric Versus Inflammatory Cells Fas Gene Expression in Iraqi Patients with Gastroduodenal Disorders. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.032
Key words: Fas gene; gastric disorders; pepsinogens; gastrin -17; H. pylori, CagA.
*Correspondence: Ali Ibrahim Ali Al-Ezzy. Department of Pathology, College of Veterinary Medicine, Diyala University, Baquba, Diyala Province, Iraq. E-mail: alizziibrahim@gmail.com
Received: 23-Jan-2016; Revised: 19-Feb-2016; Accepted: 20-Feb-2016; Online first: 15-Mar-2016
Copyright: © 2016 Ali Ibrahim Ali AL-Ezzy. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

 

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Publisher: ID Design 2012/DOOEL Skopje, Republic of Macedonia.

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