ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.030
eISSN: 1857-9655
Clinical Science
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Report on von Willebrand Disease
in Malaysia
Mercy Halleluyah Periayah1, Ahmad Sukari Halim1*,
Arman Zaharil Mat Saad1, Nik Soriani Yaacob2, Faraizah
Abdul Karim3
1Reconstructive Sciences Unit, School of Medical Sciences,
Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; 2Department
of Chemical Pathology, School of Medical Sciences, Universiti Sains
Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; 3Hemophilia
Clinic, National Blood Centre (Pusat Darah Negara), Jalan Tun Razak, 50400,
Wilayah Persekutuan, Kuala Lumpur
BACKGROUND: Von Willebrand disease (vWD) is an inherited hemostatic
disorder that affects the hemostasis pathway. The worldwide prevalence of
vWD is estimated to be 1% of the general population but only 0.002% in
Malaysia.
AIM: Our present paper has been written to disclose the statistical
counts on the number of vWD cases reported from 2011 to 2013.
MATERIAL AND METHODS: This article is based on sociodemographic data,
diagnoses and laboratory findings of vWD in Malaysia. A total of 92 patients
were reported to have vWD in Malaysia from 2011 to 2013.
RESULTS: Sociodemographic-analysis revealed that 60% were females,
63% were of the Malay ethnicity, 41.3% were in the 19-44 year old age group
and 15.2% were from Sabah, with the East region having the highest
registered number of vWD cases. In Malaysia, most patients are predominately
affected by vWD type 1 (77.2%). Factor 8, von Willebrand factor: Antigen and
vWF: Collagen-Binding was the strongest determinants in the laboratory
profiles of vWD.
CONCLUSION: This report has been done with great interest to provide
an immense contribution from Malaysia, by revealing the statistical counts
on vWD from 2011-2013.
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Citation: Periayah MH, Halim AS, Mat Saad AZ,
Yaacob NS, Abdul Karim FA. Report on von Willebrand Disease in Malaysia. OA
Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.030
Key words: von Willebrand Disease; Malaysian report; Sociodemographic
details; Laboratory profiles; Year 2011-2013.
*Correspondence: Ahmad Sukari Halim, Reconstructive Sciences Unit,
School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian,
Kelantan, Malaysia. (Tel) +60 09 7676000; (Fax) +60 09 7656434; Email:
ashalim@usm.my
Received: 09-Jan-2016; Revised: 23-Jan-2016; Accepted: 24-Jan-2016; Online
first: 29-Feb-2016
Copyright: © 2016 Mercy Halleluyah Periayah, Ahmad Sukari Halim,
Arman Zaharil Mat Saad, Nik Soriani Yaacob, Faraizah Abdul Karim.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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