[International] [Peer Reviewed] 

About OAMJMS

Our policies

OAMJMS Online

For contributors

Services

Why publish in OAMJMS?
Editors
Boards
Publication fee
Indexing
Membership
Evaluation

Editorial & publishing policies
Competing interests policy 
Open access
Open access license

Reviewer guidelines
CrossCheck Plagiarism Screening
CrossMark Policy Page

Online first
Current issue
Journal archive

Online first fact sheet
Free Registration
Contact
Webmail

Guidelines  [pdf]
Online submission MC
Online submission OJS
Help for authors
Cover letter
Reviewers of OAMJMS

Reviewer Summary

Transliteration
Subscriptions

Sponsors
Reprints and permissions
Resources
ICMJE Disclosure Form

 

ID Design 2012/DOOEL Skopje

Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2016.024
eISSN: 1857-9655

Clinical Science

 

 

Effects of Hormone Replacement Therapy on Insulin Resistance in Postmenopausal Diabetic Women


 

Iskra Bitoska*, Branka Krstevska, Tatjana Milenkovic, Slavica Subeska-Stratrova, Goran Petrovski, Sasha Jovanovska Mishevska, Irfan Ahmeti, Biljana Todorova

University Clinic of Endocrinology, Diabetology and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia

 

Abstract

 

 

BACKGROUND: Insulin resistance (IR) is closely associated with diabetes mellitus. On the other hand, increased visceral fat in menopause is also associated with IR, which makes postmenopausal diabetic women in a big risk for cardiovascular diseases. There are conflicting reports about the effects on hormone replacement therapy (HRT) on IR.

AIM: The aim of the study was to investigate the effects of HRT on IR.

METHODS: A total of 40 postmenopausal women with type 2 diabetes were enrolled and followed for 12 months. Half of them were assigned to take HRT, while the other half made the control group. Fasting plasma glucose (FPG) and insulinemia were measured in both groups at baseline and after 12 months. IR was represented by Homeostatic model assessment for IR (HOMA-IR).

RESULTS: HRT was associated with significant decrease in HOMA-IR, FPG and insulinemia in the examined group. There was no significant reduction in FPG and no significant increase in insulinemia levels and HOMA-IR values in control group after 12 months.

CONCLUSION: HRT was associated with statistically signifficant increase of insulin sensitivity. Larger clinical trials will be necessary to understand whether HRT may improve insulin resistance and glucose homeostasis in women with diabetes, especially when given shortly after entering menopause.
 

..................

Citation: Bitoska I, Krstevska B, Milenkovic T, Subeska-Stratrova S, Petrovski G, Jovanovska Mishevska S, Ahmeti I, Todorova B. Effects of Hormone Replacement Therapy on Insulin Resistance in Postmenopausal Diabetic Women. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.024
Key words: Hormone replacement therapy; Menopause; Diabetes mellitus; Insulin resistance; HOMA - IR.
*Correspondence: Dr. Iskra Bitoska. University Clinic of Endocrinology, Diabetology and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia. E-mail: ibitovska@yahoo.com
Received: 08-Jan-2016; Revised: 24-Jan-2016; Accepted: 25-Jan-2016; Online first: 01-Feb-2016
Copyright: © 2016 Iskra Bitoska, Branka Krstevska, Tatjana Milenkovic, Slavica Subeska-Stratrova, Goran Petrovski, Sasha Jovanovska Mishevska, Irfan Ahmeti, Biljana Todorova. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

 

< Previous | Next Article >

Table of contents

 

This Article (free)

Full text (pdf)

Full text OnlineFirst (pdf)


Google Scholar

- Bitoska I
- Krstevska B
- Milenkovic T
- Subeska-Stratrova S
- Petrovski G
- Jovanovska Mishevska S
- Ahmeti I
- Todorova B


PubMed

- Bitoska I
- Krstevska B
- Milenkovic T
- Subeska-Stratrova S
- Petrovski G
- Jovanovska Mishevska S
- Ahmeti I
- Todorova B

 

Altmetric
 

 


Publisher: ID Design 2012/DOOEL Skopje, Republic of Macedonia.

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

OAMJMS is an international peer-reviewed, Open Access journal published four times per year. OAMJMS Online (eISSN 1857-9655) offers free access to all articles.


Creative Commons Attribution LicenseAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.