ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.024
eISSN: 1857-9655
Clinical Science
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Effects of Hormone Replacement
Therapy on Insulin Resistance in Postmenopausal Diabetic Women
Iskra Bitoska*, Branka Krstevska, Tatjana
Milenkovic, Slavica Subeska-Stratrova, Goran Petrovski, Sasha Jovanovska
Mishevska, Irfan Ahmeti, Biljana Todorova
University Clinic of Endocrinology, Diabetology and Metabolic Disorders,
Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje,
Republic of Macedonia
BACKGROUND: Insulin resistance (IR) is closely associated with
diabetes mellitus. On the other hand, increased visceral fat in menopause is
also associated with IR, which makes postmenopausal diabetic women in a big
risk for cardiovascular diseases. There are conflicting reports about the
effects on hormone replacement therapy (HRT) on IR.
AIM: The aim of the study was to investigate the effects of HRT on
IR.
METHODS: A total of 40 postmenopausal women with type 2 diabetes were
enrolled and followed for 12 months. Half of them were assigned to take HRT,
while the other half made the control group. Fasting plasma glucose (FPG)
and insulinemia were measured in both groups at baseline and after 12
months. IR was represented by Homeostatic model assessment for IR (HOMA-IR).
RESULTS: HRT was associated with significant decrease in HOMA-IR, FPG
and insulinemia in the examined group. There was no significant reduction in
FPG and no significant increase in insulinemia levels and HOMA-IR values in
control group after 12 months.
CONCLUSION: HRT was associated with statistically signifficant
increase of insulin sensitivity. Larger clinical trials will be necessary to
understand whether HRT may improve insulin resistance and glucose
homeostasis in women with diabetes, especially when given shortly after
entering menopause.
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Citation: Bitoska I, Krstevska B, Milenkovic T,
Subeska-Stratrova S, Petrovski G, Jovanovska Mishevska S, Ahmeti I, Todorova
B. Effects of Hormone Replacement Therapy on Insulin Resistance in
Postmenopausal Diabetic Women. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.024
Key words: Hormone replacement therapy; Menopause; Diabetes mellitus;
Insulin resistance; HOMA - IR.
*Correspondence: Dr. Iskra Bitoska. University Clinic of
Endocrinology, Diabetology and Metabolic Disorders, Faculty of Medicine, Ss
Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
E-mail: ibitovska@yahoo.com
Received: 08-Jan-2016; Revised: 24-Jan-2016; Accepted: 25-Jan-2016; Online
first: 01-Feb-2016
Copyright: © 2016 Iskra Bitoska, Branka Krstevska, Tatjana Milenkovic,
Slavica Subeska-Stratrova, Goran Petrovski, Sasha Jovanovska Mishevska,
Irfan Ahmeti, Biljana Todorova.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Bitoska I
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Krstevska B
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Milenkovic T
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Subeska-Stratrova S
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Petrovski G
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Jovanovska Mishevska S
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Ahmeti I
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Todorova B
PubMed
- Bitoska I
- Krstevska B
- Milenkovic T
- Subeska-Stratrova S
- Petrovski G
- Jovanovska Mishevska S
- Ahmeti I
- Todorova B
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