ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.021
eISSN: 1857-9655
Stomatology
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Clinical Therapeutic Effects of
the Application of Doxycycline in the Treatment of Periodontal Disease
Spiro Spasovski1, Zlatanka Belazelkoska2,
Mirjana Popovska2*, Aneta Atanasovska-Stojanovska2,
Vera Radojkova-Nikolovska2, Ilijana Muratovska2,
Natasa Toseska-Spasova2, Biljana Dzipunova4, Bruno
Nikolovski3
1PHO „Fjolla Medika”, Skopje, Republic of Macedonia; 2Faculty
of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje,
Republic of Macedonia; 3PHO ETERNAdent, Skopje, Republic of
Macedonia
OBJECTIVE: To compare the therapeutic effects of the application of
doxycycline-full dose (100 mg) and sub-dose (20 mg) in the treatment of
periodontal disease.
MATERIAL AND METHODS: A total of 60 patients with periodontal disease
were examined. Patients are divided into two groups: A) treated with
antimicrobial dose of 100 mg doxycycline once daily for 30 days, and B)
treated with 2 x 20 mg/day. doxycycline, during 75 days. Among all patients
a conservative treatment was carried out and ordinated the proper dose
doxycycline in total dose during treatment from 3 gr. Index of dental plaque
by Löe-Sillness, index of gingival inflammation and gingival bleeding by
Cowell were followed.
RESULTS: Values of dental plaque in relation first examination, 10th,
20th day, 1 month and 2.5 months, showed that after 2.5 months, average
value (x = 0.83) of dental plaque in second group is slightly less than the
value (x = 0.93) of dental plaque in the first group. The average value (x =
0.17) of gingival inflammation in second group is significantly less than
the value (x = 0.50) of gingival inflammation in the first group. The
average value (x = 0.97) of gingival bleeding in patients from the first
group was significantly higher than value(x = 0.37) of gingival bleeding in
the second group.
CONCLUSION: Patients whose therapy was helped by a sub-dose
doxycycline demonstrated positive therapeutic effects on gingival
inflammation and bleeding.
..................
Citation: Spasovski S, Belazelkoska Z, Popovska M,
Atanasovska-Stojanovska A, Radojkova-Nikolovska V, Muratovska I,
Toseska-Spasova N, Dzipunova B, Nikolovski B. Clinical Therapeutic Effects
of the Application of Doxycycline in the Treatment of Periodontal Disease.
OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.021
Key words: periodontal disease; doxycycline; sub-dose; gingival
inflammation; gingival bleeding.
*Correspondence: Mirjana Popovska, Prof, PhD. Faculty of Dentistry,
Ss. Cyril and Methodius University of Skopje, 1000 Skopje, Republic of
Macedonia. Tel: +38970519304. E-mail: popovskam2002@yahoo.com
Received: 31-Oct-2015; Revised: 13-Jan-2016; Accepted: 14-Jan-2016; Online
first: 22-Jan-2016
Copyright: © 2016 Spiro Spasovski, Zlatanka Belazelkoska, Mirjana
Popovska, Aneta Atanasovska-Stojanovska, Vera Radojkova-Nikolovska, Ilijana
Muratovska, Natasa Toseska-Spasova, Biljana Dzipunova, Bruno Nikolovski.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Spasovski S
-
Belazelkoska Z
-
Popovska M
-
Atanasovska-Stojanovska A
-
Radojkova-Nikolovska V
-
Muratovska I
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Toseska-Spasova N
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Dzipunova B
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Nikolovski B
PubMed
- Spasovski S
- Belazelkoska Z
- Popovska M
- Atanasovska-Stojanovska A
- Radojkova-Nikolovska V
- Muratovska I
- Toseska-Spasova N
- Dzipunova B
- Nikolovski B
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