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ID Design 2012/DOOEL Skopje

Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2016.021
eISSN: 1857-9655

Stomatology

 

 

Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease


 

Spiro Spasovski1, Zlatanka Belazelkoska2, Mirjana Popovska2*, Aneta Atanasovska-Stojanovska2, Vera Radojkova-Nikolovska2, Ilijana Muratovska2, Natasa Toseska-Spasova2, Biljana Dzipunova4, Bruno Nikolovski3

1PHO „Fjolla Medika”, Skopje, Republic of Macedonia; 2Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje, Republic of Macedonia; 3PHO ETERNAdent, Skopje, Republic of Macedonia

 

Abstract

 

 

OBJECTIVE: To compare the therapeutic effects of the application of doxycycline-full dose (100 mg) and sub-dose (20 mg) in the treatment of periodontal disease.

MATERIAL AND METHODS: A total of 60 patients with periodontal disease were examined. Patients are divided into two groups: A) treated with antimicrobial dose of 100 mg doxycycline once daily for 30 days, and B) treated with 2 x 20 mg/day. doxycycline, during 75 days. Among all patients a conservative treatment was carried out and ordinated the proper dose doxycycline in total dose during treatment from 3 gr. Index of dental plaque by Löe-Sillness, index of gingival inflammation and gingival bleeding by Cowell were followed.

RESULTS: Values of dental plaque in relation first examination, 10th, 20th day, 1 month and 2.5 months, showed that after 2.5 months, average value (x = 0.83) of dental plaque in second group is slightly less than the value (x = 0.93) of dental plaque in the first group. The average value (x = 0.17) of gingival inflammation in second group is significantly less than the value (x = 0.50) of gingival inflammation in the first group. The average value (x = 0.97) of gingival bleeding in patients from the first group was significantly higher than value(x = 0.37) of gingival bleeding in the second group.

CONCLUSION: Patients whose therapy was helped by a sub-dose doxycycline demonstrated positive therapeutic effects on gingival inflammation and bleeding.
 

..................

Citation: Spasovski S, Belazelkoska Z, Popovska M, Atanasovska-Stojanovska A, Radojkova-Nikolovska V, Muratovska I, Toseska-Spasova N, Dzipunova B, Nikolovski B. Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.021
Key words: periodontal disease; doxycycline; sub-dose; gingival inflammation; gingival bleeding.
*Correspondence: Mirjana Popovska, Prof, PhD. Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje, Republic of Macedonia. Tel: +38970519304. E-mail: popovskam2002@yahoo.com
Received: 31-Oct-2015; Revised: 13-Jan-2016; Accepted: 14-Jan-2016; Online first: 22-Jan-2016
Copyright: © 2016 Spiro Spasovski, Zlatanka Belazelkoska, Mirjana Popovska, Aneta Atanasovska-Stojanovska, Vera Radojkova-Nikolovska, Ilijana Muratovska, Natasa Toseska-Spasova, Biljana Dzipunova, Bruno Nikolovski. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

 

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- Spasovski S
- Belazelkoska Z
- Popovska M
- Atanasovska-Stojanovska A
- Radojkova-Nikolovska V
- Muratovska I
- Toseska-Spasova N
- Dzipunova B
- Nikolovski B


PubMed

- Spasovski S
- Belazelkoska Z
- Popovska M
- Atanasovska-Stojanovska A
- Radojkova-Nikolovska V
- Muratovska I
- Toseska-Spasova N
- Dzipunova B
- Nikolovski B

 

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