ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.018
eISSN: 1857-9655
Basic Science
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Role of Cardiac Myocytes Heart
Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction
in Human Heart (Autopsy Study)
Amany Shabaiek1, Nour El-Hoda Ismael2,
Samar Elsheikh2, Hebat Allah Amin1*
1Egyptian Forensic Medicine Authority, Pathology Department,
Cairo, Egypt; 2Faculty of Medicine, Kasr El- Aini, Pathology
Department, Cairo, Egypt
BACKGROUND: Many immunohistochemical markers have been used in the
postmortem detection of early myocardial infarction.
AIM: In the present study we examined the role of Heart-type fatty
acid binding protein (H-FABP), in the detection of early myocardial
infarction.
MATERIAL AND METHODS: We obtained samples from 40 human autopsy
hearts with/ without histopathological signs of ischemia.
RESULTS: All cases of definite and probable myocardial infarction
showed a well-defined area of H-FABP depletion. All of the control cases
showed strong H-FABP expression, except two markedly autolysed myocardial
samples that showed affected antigenicity.
CONCLUSION: Thus, we suggest H-FABP as being one of the valuable
tools facing the problem of postmortem detection of early myocardial
infarction/ischemia, but not in autolysis.
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Citation: Shabaiek A, Ismael NE, Elsheikh S, Amin
HA. Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP)
in Early Myocardial Infarction in Human Heart (Autopsy Study). OA Maced J
Med Sci. http://dx.doi.org/10.3889/oamjms.2016.018
Key words: detection myocardial infarction; H-FABP;
immunohistochemistry; MI; sudden cardiac death.
*Correspondence: Dr. Hebat Allah Ahmed Amin. Egyptian Forensic
Medicine Authority, Pathology Department, Cairo, Egypt. E-mail:
hebatallahahmedamin@gmail.com
Received: 17-Dec-2015; Revised: 08-Jan-2016; Accepted: 09-Jan-2016; Online
first: 21-Jan-2016
Copyright: © 2016 Amany Shabaiek, Nour El-Hoda Ismael, Samar Elsheikh,
Hebat Allah Amin.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Shabaiek A
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Ismael NE
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Elsheikh S
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Amin HA
PubMed
- Shabaiek A
- Ismael NE
- Elsheikh S
- Amin HA
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