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ID Design 2012/DOOEL Skopje

Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2016.018
eISSN: 1857-9655

Basic Science

 

 

Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)


 

Amany Shabaiek1, Nour El-Hoda Ismael2, Samar Elsheikh2, Hebat Allah Amin1*

1Egyptian Forensic Medicine Authority, Pathology Department, Cairo, Egypt; 2Faculty of Medicine, Kasr El- Aini, Pathology Department, Cairo, Egypt

 

Abstract

 

 

BACKGROUND: Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction.

AIM: In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction.

MATERIAL AND METHODS: We obtained samples from 40 human autopsy hearts with/ without histopathological signs of ischemia.

RESULTS: All cases of definite and probable myocardial infarction showed a well-defined area of H-FABP depletion. All of the control cases showed strong H-FABP expression, except two markedly autolysed myocardial samples that showed affected antigenicity.

CONCLUSION: Thus, we suggest H-FABP as being one of the valuable tools facing the problem of postmortem detection of early myocardial infarction/ischemia, but not in autolysis.
 

..................

Citation: Shabaiek A, Ismael NE, Elsheikh S, Amin HA. Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study). OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.018
Key words: detection myocardial infarction; H-FABP; immunohistochemistry; MI; sudden cardiac death.
*Correspondence: Dr. Hebat Allah Ahmed Amin. Egyptian Forensic Medicine Authority, Pathology Department, Cairo, Egypt. E-mail: hebatallahahmedamin@gmail.com
Received: 17-Dec-2015; Revised: 08-Jan-2016; Accepted: 09-Jan-2016; Online first: 21-Jan-2016
Copyright: © 2016 Amany Shabaiek, Nour El-Hoda Ismael, Samar Elsheikh, Hebat Allah Amin. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

 

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