ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2016.013
eISSN: 1857-9655
Case Report
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Vesicoureteral Reflux Detected
with 99mTc-DTPA Renal Scintigraphy during Evaluation of Renal
Function
Nevena Manevska1*, Sinisa Stojanoski1,
Venjamin Majstorov1, Daniela Pop-Gjorcheva1, Nikolina
Zdraveska2, Dafina Kuzmanovska2
1Institute of Patophysiology and Nuclear Medicine, Faculty of
Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of
Macedonia; 2University Children's Hospital, Faculty of Medicine,
Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia
BACKGROUND: Radionuclide techniques, as direct radionuclide
cystography and 99mTc-DMSA scintigraphy, have been used in
evaluation of vesicoureteral reflux (VUR) and reflux nephropathy (RN) in
children. Dynamic 99mTc-DTPA scintigraphy is reserved for
evaluation of differential renal function and obstruction in children, where
hydronephrosis is detected by ultrasonography (US) pre- or postnatally.
CASE REPORT: Six year old boy was prenatally diagnosed with bilateral
hydronephrosis. Postnatal, severe bilateral VUR was detected by voiding
urethrocytography. US and 99mTc-DTPA scintigraphy performed in
the first month of life showed small left kidney that participated with 2%
in the global renal function. Bilateral cutaneous ureterostomy has been
performed in order to obtain good renal drainage and promote optimal renal
growth. Twelve months later, classic antireflux procedure was done. Control
99mTc-DTPA scintigraphy, 5 ys after antireflux surgery, revealed
persisting radioactivity during the diuretic phase, in the left kidney that
indicated antireflux procedure failure with VUR reappearance.
CONCLUSION: 99mTc-DTPA scintigraphy is the first method of
choice for long-term monitoring of individual kidney function in children
with VUR and other congenital urinary tract anomalies. Additionally, it can
be used as indirect radionuclide cystography when rising of radioactivity in
the kidney region, during the diuretic phase can indicate presence of VUR.
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Citation: Manevska N, Stojanoski S, Majstorov V,
Pop-Gjorcheva D, Zdraveska N, Kuzmanovska D. Vesicoureteral Reflux Detected
with 99mTc-DTPA Renal Scintigraphy during Evaluation of Renal Function. OA
Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.012
Key words: VUR; renal function; 99mTc-DTPA scintigraphy;
99mTc-DMSA scintigraphy; hydronephrosis.
*Correspondence: Dr. Nevena Manevska. Institute of Patophysiology and
Nuclear Medicine, Faculty of Medicine, Ss Cyril and Methodius University of
Skopje, Skopje, Republic of Macedonia. E-mail: nenaribi@gmail.com
Received: 31-Oct-2015; Revised: 18-Dec-2015; Accepted: 19-Dec-2015; Online
first: 31-Dec-2015
Copyright: © 2016 Nevena Manevska, Sinisa Stojanoski, Venjamin
Majstorov, Daniela Pop-Gjorcheva, Nikolina Zdraveska, Dafina Kuzmanovska.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Manevska N
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Stojanoski S
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Majstorov V
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Pop-Gjorcheva D
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Zdraveska N
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Kuzmanovska D
PubMed
- Manevska N
- Stojanoski S
- Majstorov V
- Pop-Gjorcheva D
- Zdraveska N
- Kuzmanovska D
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