Zlatica Goseva, Biserka Jovkovska Kaeva, Angelko Gjorcev, Elena Jovanovska Janeva^*, Zoran Arsovski, Sava Pejkovska, Aleksandra Tatabitovska

University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia

 

BACKGROUND: The proportion of T and B lymphocytes in pleural fluids and blood may point to the presence of local immunological phenomena in pleural disorders.

AIM: Aim of study was to evaluate the lymphocyte phenotype and the ratio between helper (CD4+) and cytotoxic/suppressor (CD8+) lymphocytes in malignant and non-malignant effusions.

MATERIAL AND METHODS: We studied 48 patients with pleural effusions. First group had 18 patients with tuberculosis pleural effusions; second group had 20 patients with malignant pleural fluids, third group had 10 patients with transudates and 30 healthy controls. We investigated the distribution of T and B lymphocytes, T cells with helper/inducer CD4 or suppresser/cytotoxic CD8 phenotypes and the CD16 subset.

RESULTS: Results showed decreases levels of CD3, CD4, and CD16 T cells in blood of patients versus healthy controls. There were increases in the percentage of the CD3 and CD4 T cells in the pleural fluid compared with values in the blood with statistical significance in tuberculous pleurisy. The values of CD8 were similar in the pleural fluid and in blood. Levels of CD16 were non-significantly higher in pleural fluid in all groups.

Citation: Goseva Z, Jovkovska Kaeva B, Gjorcev A, Jovanovska Janeva E, Arsovski Z, Pejkovska S, Tatabitovska A. Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Etiology. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2016.009
Key words: pleural effusions; lymphocyte; CD markers; malignant pleural fluid; tuberculous pleural effusions.
*Correspondence: Dr. Elena Jovanovska Janeva. University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia. E-Mail: eli.janeva@yahoo.com
Received: 15-Nov-2015; Revised: 16-Dec-2015; Accepted: 17-Dec-2015; Online first: 25-Dec-2015
Copyright: © 2016 Zlatica Goseva, Biserka Jovkovska Kaeva, Angelko Gjorcev, Elena Jovanovska Janeva, Zoran Arsovski, Sava Pejkovska, Aleksandra Tatabitovska. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

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