ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.131
eISSN: 1857-9655
Clinical Science
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Cardiovascular Autonomic
Neuropathy and Early Atherosclerosis in Adolescent Type 1 Diabetic Patient
Soha M. Abd El Dayem1*, Ahmed A. Battah2,
Abo El Magd El Bohy3
1Pediatrics Department, National Research Centre, Cairo, Egypt;
2Critical Care Department, Cairo University, Cairo, Egypt; 3Radiology
Department, Cairo University, Cairo, Egypt
AIM: To evaluate cardiovascular autonomic neuropathy (CAN) in type 1
Diabetics and to detect its relation to coronary artery calcification.
PATIENTS AND METHODS: It is a cross sectional study included 62
diabetics and 30 controls. Clinical, laboratory assessment and 24 Hr holter
were done for all patients and controls and coronary artery calcium (CAC)
scoring by multisclice CT was done for all patients only. T-test, Mann
Whitney U test, and stepwise multiple regression were used for statistical
analyses.
RESULTS: CAC score was positive in 8.1 % of patients. Heart rate
variability (HRV) was significantly lower in diabetics. All parameters of
HRV were insignificantly lower in diabetics with positive CAC score.
Patients with microalbuminuria had a significantly lower HRV. HRV had a
significant correlation with age of patients, duration of disease, HbA1, and
Qtc in diabetics.
CONCLUSION: Percentage of arrhythmia and early atherosclerosis is
high in adolescent type 1 diabetic patients. CAN is associated with early
atherosclerosis. Cardiac autonomic neuropathy is associated with older age,
longer duration, and poor glycemic control and microalbuminuria.
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Citation: Abd El Dayem SM, Battah AA, El Bohy AEM.
Cardiovascular Autonomic Neuropathy and Early Atherosclerosis in Adolescent
Type 1 Diabetic Patient. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.131
Key words: Cardiovascular autonomic neuropathy; coronary
calcification; type 1 diabetic patient.
*Correspondence: Soha M. Abd El Dayem. Professor of Pediatrics,
Consultant of diabetes and Endocrinology, Pediatrics Department, Medical
Research Division, National Research Centre, Cairo, Egypt. Telephone: +2
01006716852. E-mail: S_eldayem@Yahoo.com
Received: 20-Jul-2015; Revised: 10-Sep-2015; Accepted: 11-Sep-2015; Online
first: 13-Dec-2015
Copyright: © 2015 Soha M. Abd El Dayem, Ahmed A. Battah, Abo El Magd
El Bohy.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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