ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.129
eISSN: 1857-9655
Clinical Science
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Evaluation of Neonatal Hemolytic
Jaundice: Clinical and Laboratory Parameters
Anet Papazovska Cherepnalkovski1*, Vjekoslav
Krzelj2, Beti Zafirovska-Ivanovska3, Todor Gruev4,
Josko Markic2, Natasa Aluloska1, Nikolina Zdraveska1,
Katica Piperkovska1
1University Pediatric Clinic - Neonatology, Faculty of Medicine,
Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia;
2University Hospital Split and School of Medicine, University of
Split, Croatia; 3Institute of Epidemiology and Biostatistics,
Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje,
Republic of Macedonia; 4Institute for Clinical Biochemistry,
Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje,
Republic of Macedonia
BACKGROUND: Neonatal jaundice that occurs in ABO or Rhesus
issoimunisation has been recognized as one of the major risk factors for
development of severe hyperbilirubinemia and bilirubin neurotoxicity.
AIM: Aim of our study was to investigate clinical and laboratory
parameters associated with hemolytic jaundice due to Rh and ABO
incompatibility and compare results with the group of unspecific jaundice.
MATERIAL AND METHODS: One hundred sixty seven (167) neonatal
hyperbilirubinemia cases were included in the study, 24.6% of which
presented with ABO/Rhesus type hemolytic jaundice, and the rest with
unspecific jaundice. Evaluation included: blood count, reticulocites, serum
bilirubin, aminotransferases, blood grouping, and Coombs test, also the day
of bilirubin peak, duration of the hyperbilirubinemia, and additional
bilirubin measurements.
RESULTS: We showed significantly lower mean values of hemoglobin,
erythrocytes and hematocrit and significantly higher values of reticulocytes
in the group of ABO/Rh incompatibility compared to the group of jaundice of
unspecific etiology; also an earlier presentation and a higher-grade
jaundice in this group.
CONCLUSIONS: The laboratory profile in ABO/Rh isoimmunisation cases
depicts hemolytic mechanism of jaundice. These cases carry a significant
risk for early and severe hyperbilirubinemia and are eligible for
neurodevelopmental follow-up. Hematological parameters and blood grouping
are simple diagnostic methods that assist the etiological diagnosis of
neonatal hyperbilirubinemia.
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Citation: Papazovska Cherepnalkovski A, Krzelj V,
Zafirovska-Ivanovska B, Gruev T, Markic J, Aluloska N, Zdraveska N,
Piperkovska K. Evaluation of Neonatal Hemolytic Jaundice: Clinical and
Laboratory Parameters. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.129
Key words: hemolytic jaundice; ABO/Rh isoimmunisation; unspecific
etiology; laboratory.
*Correspondence: Dr. Anet Papazovska Cherepnalkovski. University
Pediatric Clinic - Neonatology, Vodnjanska 17, Skopje 1000, Republic of
Macedonia. E-Mail: anet.cherepnalkovski@gmail.com
Received: 31-Oct-2015; Revised: 10-Nov-2015; Accepted: 30-Nov-2015; Online
first: 02-Dec-2015
Copyright: © 2015 Anet Papazovska Cherepnalkovski, Vjekoslav Krzelj,
Beti Zafirovska-Ivanovska, Todor Gruev, Josko Markic, Natasa Aluloska,
Nikolina Zdraveska, Katica Piperkovska.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Papazovska Cherepnalkovski A;
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Krzelj V
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Zafirovska-Ivanovska B;
-
Gruev T
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Markic J
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Aluloska N
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Zdraveska N
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Piperkovska K
PubMed
- Papazovska Cherepnalkovski A
- Krzelj V
- Zafirovska-Ivanovska B
- Gruev T
- Markic J
- Aluloska N
- Zdraveska N
- Piperkovska K
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