[International] [Peer Reviewed] 

About OAMJMS

Our policies

OAMJMS Online

For contributors

Services

Why publish in OAMJMS?
Editors
Boards
Publication fee
Indexing
Membership
Evaluation

Editorial & publishing policies
Competing interests policy 
Open access
Open access license

Reviewer guidelines
CrossCheck Plagiarism Screening
CrossMark Policy Page

Online first
Current issue
Journal archive

Online first fact sheet
Free Registration
Contact
Webmail

Guidelines  [pdf]
Online submission MC
Online submission OJS
Help for authors
Cover letter
Reviewers of OAMJMS

Reviewer Summary

Transliteration
Subscriptions

Sponsors
Reprints and permissions
Resources
ICMJE Disclosure Form

 

ID Design 2012/DOOEL Skopje

Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2015.129
eISSN: 1857-9655

Clinical Science

 

 

Evaluation of Neonatal Hemolytic Jaundice: Clinical and Laboratory Parameters


 

Anet Papazovska Cherepnalkovski1*, Vjekoslav Krzelj2, Beti Zafirovska-Ivanovska3, Todor Gruev4, Josko Markic2, Natasa Aluloska1, Nikolina Zdraveska1, Katica Piperkovska1

1University Pediatric Clinic - Neonatology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia; 2University Hospital Split and School of Medicine, University of Split, Croatia; 3Institute of Epidemiology and Biostatistics, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia; 4Institute for Clinical Biochemistry, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia

 

Abstract

 

 

 

BACKGROUND: Neonatal jaundice that occurs in ABO or Rhesus issoimunisation has been recognized as one of the major risk factors for development of severe hyperbilirubinemia and bilirubin neurotoxicity.

AIM: Aim of our study was to investigate clinical and laboratory parameters associated with hemolytic jaundice due to Rh and ABO incompatibility and compare results with the group of unspecific jaundice.

MATERIAL AND METHODS: One hundred sixty seven (167) neonatal hyperbilirubinemia cases were included in the study, 24.6% of which presented with ABO/Rhesus type hemolytic jaundice, and the rest with unspecific jaundice. Evaluation included: blood count, reticulocites, serum bilirubin, aminotransferases, blood grouping, and Coombs test, also the day of bilirubin peak, duration of the hyperbilirubinemia, and additional bilirubin measurements.

RESULTS: We showed significantly lower mean values of hemoglobin, erythrocytes and hematocrit and significantly higher values of reticulocytes in the group of ABO/Rh incompatibility compared to the group of jaundice of unspecific etiology; also an earlier presentation and a higher-grade jaundice in this group.

CONCLUSIONS: The laboratory profile in ABO/Rh isoimmunisation cases depicts hemolytic mechanism of jaundice. These cases carry a significant risk for early and severe hyperbilirubinemia and are eligible for neurodevelopmental follow-up. Hematological parameters and blood grouping are simple diagnostic methods that assist the etiological diagnosis of neonatal hyperbilirubinemia.
 

..................

Citation: Papazovska Cherepnalkovski A, Krzelj V, Zafirovska-Ivanovska B, Gruev T, Markic J, Aluloska N, Zdraveska N, Piperkovska K. Evaluation of Neonatal Hemolytic Jaundice: Clinical and Laboratory Parameters. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.129
Key words: hemolytic jaundice; ABO/Rh isoimmunisation; unspecific etiology; laboratory.
*Correspondence: Dr. Anet Papazovska Cherepnalkovski. University Pediatric Clinic - Neonatology, Vodnjanska 17, Skopje 1000, Republic of Macedonia. E-Mail: anet.cherepnalkovski@gmail.com
Received: 31-Oct-2015; Revised: 10-Nov-2015; Accepted: 30-Nov-2015; Online first: 02-Dec-2015
Copyright: © 2015 Anet Papazovska Cherepnalkovski, Vjekoslav Krzelj, Beti Zafirovska-Ivanovska, Todor Gruev, Josko Markic, Natasa Aluloska, Nikolina Zdraveska, Katica Piperkovska.   This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

 

< Previous | Next Article >

Table of contents

 

This Article (free)

Full text (pdf)

Full text OnlineFirst (pdf)


Google Scholar

- Papazovska Cherepnalkovski A;
- Krzelj V
- Zafirovska-Ivanovska B;
- Gruev T
- Markic J
- Aluloska N
- Zdraveska N
- Piperkovska K


PubMed

- Papazovska Cherepnalkovski A
- Krzelj V
- Zafirovska-Ivanovska B
- Gruev T
- Markic J
- Aluloska N
- Zdraveska N
- Piperkovska K

 

Altmetric
 

 


Publisher: ID Design 2012/DOOEL Skopje, Republic of Macedonia.

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

OAMJMS is an international peer-reviewed, Open Access journal published four times per year. OAMJMS Online (eISSN 1857-9655) offers free access to all articles.


Creative Commons Attribution LicenseAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.