Background: Adipokines provides new insights about the physiology, pathology and treatment of obesity.

Aim: We investigated the association between serum vaspin and serum visfatin concentrations with obesity in Egyptian children.

Material and Methods: Twenty two obese children with body mass index (BMI) above 95th percentile; 11 males and 11 females were included in this study. Their mean age was 9.18 ± 2.8 years. After general clinical examination, fasting blood glucose, triglycerides, total cholesterol and high density lipoprotein cholesterol were measured in cases and controls (n=11). Fasting insulin, vaspin and visfatin were detected using ELIZA. Insulin resistance was estimated by Homeostasis model assessment method (HOMA-IR).

Results: Blood pressure, in both systolic and diastolic measurements was elevated significantly in obese children. Significant elevation of serum insulin and insulin resistance (HOMA/IR) were observed in obese children too. Vaspin and visfatin showed significant elevation in obese children than controls. Significant positive correlations were detected between visfatin and BMI, waist circumference, hip circumference and HOMA/IR. We found that Vaspin and visfatin are higher in obese children.

Citation: Salama HM, Galal A, Motawie AA, Kamel AF, Ibrahim DM, Aly AA, Hassan EA.. Adipokines Vaspin and Visfatin in Obese Children. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.123
Key words: Vaspin; visfatin; obese; children; adipokines.
*Correspondence: Prof. Hassan Mohamed Salama. NRC, Pediatrics, Cairo 19961, Egypt. Phone: +201006514147. E-Mail: hsalama27@gmail.com
Received: 10-Nov-2013; Revised: 19-Feb-2014; Accepted: 20-Feb-2014; Online first: 26-Nov-2015
Copyright: © 2015 Hassan Hassan M. Salama, Ashraf Galal, Ayat A. Motawie, Ashraf F. Kamel, Doaa M. Ibrahim, Azza A. Aly, Emman A. Hassan.   This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

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