ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.109
eISSN: 1857-9655
Clinical Science
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Role and Significance of Markers
of Inflammation in the Asthmatic Disease
Zlatica Goseva, Elena Jovanovska Janeva*,
Angelko Gjorcev, Zoran Arsovski, Sava Pejkovska
PHI University Clinic of Pulmonology and Allergology, Faculty of Medicine,
Ss Cyril and Methodius University of Skopje, Republic of Macedonia
BACKGROUND: Asthma is characterized by airway inflammation which can
be reversible.
AIM: Investigation the importance of eosinophils, ECP and IL-5 in asthmatics
versus patients with obstructive bronchitis and healthy subjects. We
investigated the values before and after the treatment in asthmatics.
MATERIAL AND METHODS: We studied 77 subjects divided in three groups
as follows: 1) asthma patients; 2) patients with obstructive bronchitis and
3) control group of healthy subjects. In all the subjects there were
determined: Total number of eosinophils (Eo), eosinophilic cationic protein
(ECP), Interleukin 5 (IL-5) and allergy tests.
RESULTS: The total number of eosinophils was significantly increased
in the group of asthma patients versus second and third group. We found that
the presence of ECP demonstrate an ongoing inflammation, with or without
clinical symptoms of asthma patients. There was significant difference
between the values of ECP of asthma patients versus second and third group.
Our results have shown that IL-5 was significantly increased versus second
group and controls (p < 0.01). We also found the decrease of the values of
inflammatory markers after the treatment with corticosteroids.
CONCLUSIONS: Eosinophils, ECP and IL-5 could be useful markers for
selecting allergic patients and could be the monitors of treatment effects.
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Citation: Goseva Z, Jovanovska Janeva E, Gjorcev
A, Arsovski Z, Pejkovska S. Role and Significance of Markers of Inflammation
in the Asthmatic Disease. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.109
Key words: asthma; markers; inflammation; eosinophil; eosinophil
cationic protein; IL-5.
*Correspondence: Elena Jovanovska Janeva, MD, MSc. University Clinic
of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius
University of Skopje, Skopje, Republic of Macedonia. E-mail: eli.janeva@yahoo.com
Received: 05-Oct-2015; Revised: 09-Oct-2015; Accepted: 13-Oct-2015; Online
first: 21-Oct-2015
Copyright: © 2015 Zlatica Goseva, Elena Jovanovska Janeva, Angelko
Gjorcev, Zoran Arsovski, Sava Pejkovska.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Goseva Z
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Jovanovska Janeva E
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Gjorcev A
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Arsovski Z
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Pejkovska S
PubMed
- Goseva Z
- Jovanovska Janeva E
- Gjorcev A
- Arsovski Z
- Pejkovska S
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