ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.103
eISSN: 1857-9655
Clinical Science
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Newly Diagnosed Diabetes and
Stress Glycaemia and Its’ Association with Acute Coronary Syndrome
Gordana Kamceva1, Marija Vavlukis2*,
Darko Kitanoski2, Sashko Kedev2
1University "Goce Delchev", Faculty of Medical Sciences, Clinical
Hospital Shtip, Shtip, Republic of Macedonia; 2Ss Cyril and
Methodius University of Skopje, Faculty of Medicine, University Clinic for
Cardiology, Skopje, Republic of Macedonia
BACKGROUND: Diabetes is diagnosed in 10-20% of patients with acute
coronary syndrome (ACS) not known to be diabetics. Elevated blood glucose is
an independent risk factor for cardiac events, regardless of presence of
diabetes.
AIM: Evaluating the prevalence of new-diagnosed DM among patients
with ACS, and assessing the relationship between stress glycaemia and new
diagnosed DM with in-hospital cardiac events.
METHODS: Prospective observational study, in patients with ACS, in
whom we analyzed parameters of glycemic metabolism, clinical data, and
in-hospital cardiac events. We comparatively analyzed patients according to
the HgbA1C and known DM in five groups: non-DM (< 5.6%), new pre-DM
(5.6-6.5%), new DM (≥ 6.5%), controlled (<7%) and uncontrolled (≥7%) known
DM.
RESULTS: 150 patients, (93 male and 57 female) were included.
Impaired glucose metabolism was detected in 44.5% of patients, 7.9% of whom
were newly-diagnosed DM. The highest levels of stress glycaemia were found
in new and uncontrolled known DM. The in-hospital event rate was 20.7%, the
mortality rate 7.3%, being the highest in new diagnosed and uncontrolled
known DM patients.
CONCLUSIONS: The prevalence of unknown DM was high among patients
with ACS. Stress glycaemia and failure to achieve glycemic controlee, were
an independent predictors of in-hospital cardiac events.
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Citation: Kamceva G, Vavlukis M, Kitanoski D,
Kedev S. Newly Diagnosed Diabetes and Stress Glycaemia and Its’ Association
with Acute Coronary Syndrome. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.103
Key words: diabetes mellitus; stress glycaemya; hemoglobin A1C; acute
coronary syndrome; cardiac events.
*Correspondence: Dr. Marija Vavlukis. UC of Cardiology, ICCU, Mother
Theresa 17, Skopje 1000, Republic of Macedonia. Phone: 003892 3113116. Fax:
003892 3164134. E-Mail: marija.vavlukis@gmail.com
Received: 20-Sep-2015; Revised: 23-Sep-2015; Accepted: 24-Sep-2015; Online
first: 30-Sep-2015
Copyright: © 2015 Gordana Kamceva, Marija Vavlukis, Darko Kitanoski,
Sashko Kedev. This is an open access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Vavlukis M
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Kitanoski D
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