ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.102
eISSN: 1857-9655
Basic Science
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Dysplasia in Gastric Mucosa and
its Reporting Problems
Majlinda Ikonomi1, Blerina Cela1*,
Dhurata Tarifa2
1Histopathology Laboratory, Oncology Service, Tirana, Albania;
2Oncology Service, Chemotherapy, Tirana, Albania
BACKGROUND: The recognition, terminology used and histopathologic
evaluation of two essential elements in gastric carcinogenesis, atrophy and
dysplasia, are characterized by controversy.
MATERIALS AND METHODS: One hundred fifteen cases, with slides and
their histopathologic reports from the archive of the Laboratory of
Pathology were studied for the diagnostic value, reporting of dysplasia,
interobserver variability, the relation of dysplastic lesions with
inflammation, atrophy and metaplasia. After retrospectively studying the
histopathologic reports from the archive we distributed the cases according
to endoscopic and histopathologic diagnosis, together with the reexamination
of the slides. The comparison of the median values of the numeric variables
was made with the Mann-Whitney test (non-parametric equivalent of the
Student’s “t” test).
RESULTS: The endoscopic clinical diagnosis were:
malignancy/suspicious for malignancy 88 cases (76%) and non-neoplastic
diagnosis (like ulcer or gastritis) 27 cases (24%). From the reexamination
of the cases it resulted that there is no difference in reporting the
malignancy, but there is a difference in the cases reported as dysplasia (p
= 0.001) and negative for neoplasia (p = 0.063, borderline).
CONCLUSION: Clinicians and pathologists can feel directly the
discrepancy called “interobserver variability” and should be assured that
the use of guidelines will cause a lowering of this variability.
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Citation: Ikonomi M, Cela B, Tarifa D. Dysplasia
in Gastric Mucosa and its Reporting Problems. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.102
Key words: gastric dysplasia; gastric cancer; interobserver
variability; dysplasia; neoplasia.
*Correspondence: Dr. BLERINA CELA. TIRANE 1000, Albania. E-Mail:
celablerina@yahoo.com
Received: 14-Sep-2015; Revised: 29-Oct-2015; Accepted: 30-Oct-2015; Online
first: 11-Nov-2015
Copyright: © 2015 Majlinda Ikonomi, Blerina Cela, Dhurata Tarifa.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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