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Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.098
eISSN: 1857-9655
Clinical Science
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Study of Adiponectin Level in Diabetic Adolescent Girls in Relation to
Glycemic Control and Complication of Diabetes
Soha M. Abd El Dayem1*, Hayam K. Nazif2,
Mone Abd EI-Kader3, Maha El-Tawil4
1Pediatrics Department, National Research Centre, Cairo, Egypt;
2Pediatrics Department, Institute of Postgraduate Childhood
Studies Ain Shams University, Cairo, Egypt; 3Clinical and
Biochemical Department, National Research Centre, Cairo, Egypt; 4Pediatrics
Department, Police Hospital, Cairo, Egypt
AIM: To study the relation between adiponectin level with glycemic
control and complication of diabetes.
PATIENTS AND METHODS: The study included 40 female adolescent type 1
diabetic patients and 40 healthy volunteers of the same age and sex. Blood
sample was taken for assessment of glycosylated hemoglobin, lipid profile
and adiponectine. Urine sample was taken for assessment of albumin/
creatinine ratio.
RESULTS: Diabetic patients had a significantly higher diastolic blood
pressure, triglyceride, total cholesterol, LDL and adiponectin than
controls. Patients with diabetes complication had a significant lower BMI
and HDL. On the other hand, they had higher disease duration, total
cholesterol, HbA1, albumin/creatinine ratio and adiponectin. Patients with
microalbuminuria had a lower BMI, higher disease duration, diastolic blood
pressure and adiponectin. Patients with diabetic retinopathy had higher
disease duration, insulin dose, HbA1, microalbuminuria and adiponectin.
Adiponectin in diabetic patients had a significant negative correlation with
BMI and positive correlation with systolic blood pressure and
microlabuminuria.
CONCLUSION: Serum adiponectin level is high in adolescent type 1
diabetic girls. It can be used as a predictor of diabetes complications
rather than a sensitive biochemical marker for glycemic control.
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Citation: El Dayem SM, Nazif HK, EI-Kader MA, El-Tawil
M. Study of Adiponectin Level in Diabetic Adolescent Girls in Relation to
Glycemic Control and Complication of Diabetes. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.098
Key words: Adiponectin; Glycemic Control; complication; type 1
diabetes.
*Correspondence: Soha M. Abd El Dayem. Professor of Pediatrics,
Consultant of diabetes and Endocrinology, Pediatrics Department, Medical
Research Division, National Research Centre, Cairo, Egypt. Telephone: +2
01006716852. E-mail: S_eldayem@Yahoo.com
Received: 01-Jun-2015; Revised: 18-Jul-2015; Accepted: 19-Jul-2015; Online
first: 02-Oct-2015
Copyright: © 2015 Soha M. Abd El Dayem, Hayam K. Nazif, Mone Abd EI-Kader,
Maha El-Tawil. This is an open access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.
Competing Interests: The authors have declared that no competing
interests exist.
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