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ID Design 2012/DOOEL Skopje

Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2015.098
eISSN: 1857-9655

Clinical Science

 

 

Study of Adiponectin Level in Diabetic Adolescent Girls in Relation to Glycemic Control and Complication of Diabetes


 

Soha M. Abd El Dayem1*, Hayam K. Nazif2, Mone Abd EI-Kader3, Maha El-Tawil4

1Pediatrics Department, National Research Centre, Cairo, Egypt; 2Pediatrics Department, Institute of Postgraduate Childhood Studies Ain Shams University, Cairo, Egypt; 3Clinical and Biochemical Department, National Research Centre, Cairo, Egypt; 4Pediatrics Department, Police Hospital, Cairo, Egypt

 

Abstract

 

 

AIM: To study the relation between adiponectin level with glycemic control and complication of diabetes.

PATIENTS AND METHODS: The study included 40 female adolescent type 1 diabetic patients and 40 healthy volunteers of the same age and sex. Blood sample was taken for assessment of glycosylated hemoglobin, lipid profile and adiponectine. Urine sample was taken for assessment of albumin/ creatinine ratio.

RESULTS: Diabetic patients had a significantly higher diastolic blood pressure, triglyceride, total cholesterol, LDL and adiponectin than controls. Patients with diabetes complication had a significant lower BMI and HDL. On the other hand, they had higher disease duration, total cholesterol, HbA1, albumin/creatinine ratio and adiponectin. Patients with microalbuminuria had a lower BMI, higher disease duration, diastolic blood pressure and adiponectin. Patients with diabetic retinopathy had higher disease duration, insulin dose, HbA1, microalbuminuria and adiponectin. Adiponectin in diabetic patients had a significant negative correlation with BMI and positive correlation with systolic blood pressure and microlabuminuria.

CONCLUSION: Serum adiponectin level is high in adolescent type 1 diabetic girls. It can be used as a predictor of diabetes complications rather than a sensitive biochemical marker for glycemic control.
 

..................

Citation: El Dayem SM, Nazif HK, EI-Kader MA, El-Tawil M. Study of Adiponectin Level in Diabetic Adolescent Girls in Relation to Glycemic Control and Complication of Diabetes. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.098
Key words: Adiponectin; Glycemic Control; complication; type 1 diabetes.
*Correspondence: Soha M. Abd El Dayem. Professor of Pediatrics, Consultant of diabetes and Endocrinology, Pediatrics Department, Medical Research Division, National Research Centre, Cairo, Egypt. Telephone: +2 01006716852. E-mail: S_eldayem@Yahoo.com
Received: 01-Jun-2015; Revised: 18-Jul-2015; Accepted: 19-Jul-2015; Online first: 02-Oct-2015
Copyright: © 2015 Soha M. Abd El Dayem, Hayam K. Nazif, Mone Abd EI-Kader, Maha El-Tawil. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

 

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Publisher: ID Design 2012/DOOEL Skopje, Republic of Macedonia.

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