[International] [Peer Reviewed] 

About OAMJMS

Our policies

OAMJMS Online

For contributors

Services

Why publish in OAMJMS?
Editors
Boards
Publication fee
Indexing
Membership
Evaluation

Editorial & publishing policies
Competing interests policy 
Open access
Open access license

Reviewer guidelines
CrossCheck Plagiarism Screening
CrossMark Policy Page

Online first
Current issue
Journal archive

Online first fact sheet
Free Registration
Contact
Webmail

Guidelines  [pdf]
Online submission MC
Online submission OJS
Help for authors
Cover letter
Reviewers of OAMJMS

Reviewer Summary

Transliteration
Subscriptions

Sponsors
Reprints and permissions
Resources
ICMJE Disclosure Form

 

ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.

http://dx.doi.org/10.3889/oamjms.2015.092

eISSN: 1857-9655

Clinical Science

 

 

Bone Density, Osteocalcin and Deoxypyridinoline for Early Detection of Osteoporosis in Obese Children


 

Ghada El-Dorry1, Hala Ashry2, Tarek Ibrahim2*, Tahany Elias3, Fatma Alzaree2

1Institute of Postgraduate Childhood Studies, Ain Shams University, Medical Studies Department, Cairo, Egypt; 2National Research Center, Child Health Department, Cairo, Egypt; 3National Research Center, Medical Biochemistry Department, Cairo, Egypt

 

Abstract

 

 

AIM: This study aimed at comparing between bone density using DEXA, serum osteocalcin and urinary DPD in obese and non obese prepubertal children.

METHODS: After taking the consent of eighty children they were subjected to: full examination, anthropometric measurements, blood samples were withdrawn to determine serum osteocalcin, Ca, Ph, alkaline phosphatase, and urinary DPD. Bone densities, body composition of the whole body were examined using DEXA. Data were analyzed using SPSS.

RESULTS: All anthropometric variables showed significant increase in obese children except for height in comparison to control group. Total mass, lean + BMC, lean, fat, area, BMC, BMD and Z score of the whole body were significantly increased in obese children. Serum calcium showed significant increase while alkaline phosphatase was significantly decreased in obese children. DPD showed no significant difference between obese and non obese children. Significant negative correlation was found between ca, lean, lean + BMC and total mass. Serum alkaline phosphatase showed also a significant negative correlation with (lean + BMC and total mass). Serum osteocalcin showed negative significant correlation with area, BMC, BMD, lean and Z score.

CONCLUSION: Obese children showed significant increase in anthropometric and DEXA parameters, increase in serum calcium and significant decrease in serum alkaline phosphatase. Osteocalcin was negatively correlated with most of DEXA results.
 

..................

Citation: El-Dorry G, Ashry H, Ibrahim T, Elias T, Alzaree F. Bone Density, Osteocalcin and Deoxypyridinoline for Early Detection of Osteoporosis in Obese Children. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.092
Key words: DEXA parameters; osteocalcin; calcium; phosphorus; alkaline phosphatise; obese Egyptian children.
*Correspondence: Prof. Tarek Salah Ibrahim. National Research Centre, Child Health, Tahrir Street, Cairo, Doki 1178, Egypt. Phone: 01004212181. E-Mail: tareksalah2000@yahoo.com
Received: 02-Jul-2015; Revised: 05-Aug-2015; Accepted: 06-Aug-2015; Online first: 07-Sep-2015
Copyright: © 2015 Ghada El-Dorry, Hala Ashry, Tarek Ibrahim, Tahany Elias, Fatma Alzaree.   This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

 

< Previous | Next Article >

Table of contents

 

This Article (free)

Full text (pdf)

Full text OnlineFirst (pdf)


Google Scholar

- El-Dorry G
- Ashry H
- Ibrahim T
- Elias T
- Alzaree F


PubMed

- El-Dorry G
- Ashry H
- Ibrahim T
- Elias T
- Alzaree F

 

Altmetric
 

 


Publisher: ID Design 2012/DOOEL Skopje, Republic of Macedonia.

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

OAMJMS is an international peer-reviewed, Open Access journal published four times per year. OAMJMS Online (eISSN 1857-9655) offers free access to all articles.


Creative Commons Attribution LicenseAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.