ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.092
eISSN: 1857-9655
Clinical Science
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Bone Density, Osteocalcin and Deoxypyridinoline for Early Detection of
Osteoporosis in Obese Children
Ghada El-Dorry1, Hala Ashry2, Tarek
Ibrahim2*, Tahany Elias3, Fatma Alzaree2
1Institute of Postgraduate Childhood Studies, Ain Shams
University, Medical Studies Department, Cairo, Egypt; 2National
Research Center, Child Health Department, Cairo, Egypt; 3National
Research Center, Medical Biochemistry Department, Cairo, Egypt
AIM: This study aimed at comparing between bone
density using DEXA, serum osteocalcin and urinary DPD in obese and non obese
prepubertal children.
METHODS: After taking the consent of eighty
children they were subjected to: full examination, anthropometric
measurements, blood samples were withdrawn to determine serum osteocalcin,
Ca, Ph, alkaline phosphatase, and urinary DPD. Bone densities, body
composition of the whole body were examined using DEXA. Data were analyzed
using SPSS.
RESULTS: All anthropometric variables showed
significant increase in obese children except for height in comparison to
control group. Total mass, lean + BMC, lean, fat, area, BMC, BMD and Z score
of the whole body were significantly increased in obese children. Serum
calcium showed significant increase while alkaline phosphatase was
significantly decreased in obese children. DPD showed no significant
difference between obese and non obese children. Significant negative
correlation was found between ca, lean, lean + BMC and total mass. Serum
alkaline phosphatase showed also a significant negative correlation with
(lean + BMC and total mass). Serum osteocalcin showed negative significant
correlation with area, BMC, BMD, lean and Z score.
CONCLUSION: Obese children showed significant
increase in anthropometric and DEXA parameters, increase in serum calcium
and significant decrease in serum alkaline phosphatase. Osteocalcin was
negatively correlated with most of DEXA results.
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Citation: El-Dorry G, Ashry H, Ibrahim T,
Elias T, Alzaree F. Bone Density, Osteocalcin and Deoxypyridinoline for
Early Detection of Osteoporosis in Obese Children. OA Maced J Med Sci.
http://dx.doi.org/10.3889/oamjms.2015.092
Key words: DEXA parameters; osteocalcin; calcium; phosphorus;
alkaline phosphatise; obese Egyptian children.
*Correspondence: Prof. Tarek Salah Ibrahim. National Research Centre,
Child Health, Tahrir Street, Cairo, Doki 1178, Egypt. Phone: 01004212181.
E-Mail: tareksalah2000@yahoo.com
Received: 02-Jul-2015; Revised: 05-Aug-2015; Accepted: 06-Aug-2015; Online
first: 07-Sep-2015
Copyright: © 2015 Ghada El-Dorry, Hala Ashry, Tarek Ibrahim, Tahany
Elias, Fatma Alzaree.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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El-Dorry G
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Ashry H
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Ibrahim T
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Elias T
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Alzaree F
PubMed
- El-Dorry G
- Ashry H
- Ibrahim T
- Elias T
- Alzaree F
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