Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.088
eISSN: 1857-9655
Clinical Science
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Bifidobacterium lactis
in Treatment of Children with Acute Diarrhea. A Randomized Double Blind
Controlled Trial
Neveen Helmy Abou El-Soud1*, Reem Nabil Said2,
Dalia Sayed Mosallam2, Nahla Abdel Moniem Barakat3,
Mohamed Ahmed Sabry1
1Complementary Medicine Department, Medical Researches Division,
National Research Center, El-Behouth Street, 12311 Cairo, Egypt; 2Pediatric
Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 3Pediatric
Department, National Research Center, El-Behouth Street, 12311 Cairo, Egypt
BACKGROUND: Probiotics are becoming increasingly popular treatment
for children diarrhea. Although there are several probiotic strains
potentially useful, researches were often limited to certain strains.
AIM: To test Bifidobacterium lactis on morbidity of acute diarrhea in
children less than 2 years.
SUBJECTS AND METHODS: A randomized double-blind controlled clinical
trial was conducted in 50 children (1 - 23 months) admitted with acute
diarrhea to the Pediatric Hospital, Cairo University and were randomly
assigned to receive in addition to usual treatment of diarrhea according to
WHO guidelines; one of two treatments either milk formula non-supplemented
(n = 25) or supplemented (n = 25) with Bifidobacterium lactis 14.5 x
106 CFU/100 ml daily for one week. Primary outcomes were
frequency and duration of diarrhea and hospital stay. Secondary outcomes
were duration of fever and vomiting episodes. Safety and tolerance were also
recorded.
RESULTS: On admission, patients’ characteristics of both groups (50
cases) were similar. For children who received the probiotics for one week;
mean duration of diarrhoea was shorter than in controls (3.12 ± 0.92 vs.
4.10 ± 0.94 days) (P = 0.02), number of motions per day was less than in
controls (3.96 ± 0.62 vs. 4.46 ± 0.85) (P = 0.04) and discharge from
hospital <2 days was more frequent than in controls (72% vs. 44%) (P =
0.048). There was no effect on fever (P = 0.63) or vomiting (P = 0.54).
CONCLUSION: Bifidobacterium lactis probiotics in supplemented
milk formula decreased significantly frequency, duration of diarrhea, and
hospital stay than usual treatment alone in children with acute diarrhea.
Additional researches on other uncommon local probiotic species should be
encouraged.
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Citation: Abou El-Soud NH, Said RN, Mosallam
DS, Barakat NAM, Sabry MA. Bifidobacterium lactis in Treatment of Children
with Acute Diarrhea. A Randomized Double Blind Controlled Trial. OA Maced J
Med Sci. http://dx.doi.org/10.3889/oamjms.2015.088
Key words: probiotics; Bifidobacterium lactis; acute diarrhea;
children.
*Correspondence: Prof. Dr. Neveen Helmy Abou El-Soud. Complementary
Medicine Department, Medical Researches Division, National Research Center,
El-Behouth Street, 12311 Cairo, Egypt. Tel: +02201224359509. E-mail:
neveenster@gmail.com
Received: 09-Jun-2015; Revised: 10-Jul-2015; Accepted: 24-Jul-2015; Online
first: 07-Aug-2015
Copyright: © 2015 Neveen Helmy Abou El-Soud, Reem Nabil Said, Dalia
Sayed Mosallam, Nahla Abdel Moniem Barakat, Mohamed Ahmed Sabry.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Abou El-Soud NH
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Said RN
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Mosallam DS
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Barakat NAM
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Sabry MA
PubMed
- Abou El-Soud NH
- Said RN
- Mosallam DS
- Barakat NAM
- Sabry MA
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