Ahmed Salman^*, Mona Hegazy, Soheir AbdElfadl

Faculty of Medicine, Cairo University, Internal Medicine, Cairo, Egypt

 

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent cause of liver disease, nonalcoholic steatohepatitis (NASH) and fibrosis in obese patients identifies the risk group with increased incidence of liver-related deaths.

AIM: To clarify the role of serum adiponectin and its receptor liver gene expression in the progression of liver damage in NAFLD.

METHODS: Fifty four (54) obese patients with NAFLD preliminary diagnosed by liver ultra-sound were recruited. Full medical history, anthropometric measurement, biochemical studies, serum adiponectin level, liver biopsy for histological examination and NAS score to identify NASH patients, and assessment of adiponectin receptor gene expression by RT-PCR, were conducted for each patients. Fifteen ages matched average weight healthy adult had been chosen as a control for serum adiponectin level.

RESULTS: According to NAS score, patients were divided into non- NASH (8 patients), and NASH (46 patients). Serum adiponectin level was significantly lower in NAFLD patients compared to normal participants (p < 0.004). Serum adiponectin level was lower in NASH patients (4.437 ± 2.569 ng/dl in NASH vs. 5.138 ± 2.841 ng/dl in non-NASH). Adiponectin receptor liver gene expression was lower in NASH patients (0.8459 ± 0.4671 vs. 1.0688 ± 0.3965 in non-NASH).

CONCLUSION: Both adiponectin deficiency and resistance had a role in progression of simple liver steatosis to severe injury in obese patients.
 

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Citation: Salman A, Hegazy M, AbdElfadl S. Combined Adiponectin Deficiency and Resistance in Obese Patients: Can It Solve Part of the Puzzle in Nonalcoholic Steatohepatitis. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.057
Key words: Combined adiponectin deficiency and resistance in obese patients; can it solve part of the puzzle in NASH.
*Correspondence: Dr. Ahmed Abd allah Salman. Faculty of Medicine, Cairo University, Internal Medicine Hospital, Kasr Alainy, Cairo 12345, Egypt. Phone: 01000468664. E-Mail: awea84@kasralainy.edu.eg
Received: 29-Mar-2015; Revised: 07-Mar-2015; Accepted: 08-Apr-2015; Online first: 30-May-2015
Copyright: © 2015 Ahmed Salman, Mona Hegazy, Soheir AbdElfadl. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

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