Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.045
Basic Science
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Total IgE Distribution in Food
Allergy Suspected Patients in Republic of Macedonia (2001-2011)
Slavica Hristomanova Mitkovska*, Dejan Trajkov,
Aleksandar Petlichkovski, Olivija Efinska-Mladenovska, Mirko Spiroski
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss Cyril
and Methodius University of Skopje, Skopje, Republic of Macedonia
BACKGROUND: IgE may be considered the hallmark of allergic disorders.
It is easily detected in serum and can be measured as total IgE and as
allergen-specific IgE. In fact, the serum IgE assay is used to diagnose an
allergy.
AIM: The aim of this study is to evaluate, investigate and present
the distribution of total serum IgE levels, determined with UniCap system,
in food-allergy suspected patients in a Republic of Macedonia.
MATERIAL AND METHODS: In this study we analyzed retrospectively 8898
consecutive patients that were admitted for allergy testing at the Institute
of Immunobiology and Human Genetics during the ten year period between
01.01.2001 and 01.01.2011. Total IgE levels in patient sera were detected
with the in vitro system UniCAP100 (Pharmacia, Uppsala, Sweden).
RESULTS: When we analyzed the number of patients according to the
total IgE groups, we noted that most of the patients have normal levels of
total IgE in serum. However, we also discovered a group of patients with
elevated levels of total IgE that are greater than 200 kU/L. The average
concentration of total serum IgE is higher in women in the age group 6 (6-7
years), followed by a steep decrease in the age group 9 (9-10 years), and
after that the average concentrations of total IgE were mostly constant with
the exception of a partial increase in the age group 21 (65-69 years). For
men, the average serum concentrations of total IgE were highest in the age
group of 6 (6-7 years), which was significantly higher than the average
concentrations of total IgE in all other age groups.
CONCLUSION: The large number of enrolled patients, a particular
strength of this study, revealed that average concentrations of total IgE in
men are higher than in women and that total IgE did not decrease with age.
On the contrary, increased total IgE levels were found in patients aged 65
and 69 of both genders. We continue our work with analyses of the specific
IgE antibodies values toward food and the correlation with total IgE values.
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Citation: Hristomanova Mitkovska S, Trajkov
D, Petlichkovski A, Efinska-Mladenovska O, Spiroski
M. Total IgE Distribution in Food Allergy Suspected Patients in Republic of
Macedonia (2001-2011). OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.045
Key words: IgE-mediated food allergy; total IgE; specific IgE
antibodies to allergens from foods of plant origin; IgE antibodies to
allergens from foods of animal origin; Republic of Macedonia.
*Correspondence: Assist. Dr. Slavica Hristomanova Mitkovska.
Institute of Immunobiology and Human Genetics, Medical Faculty, St. Cyril
and Methodius University of Skopje, Skopje, Republic of Macedonia. E-mail:
cacka_h@yahoo.com
Received: 14-Feb-2015; Revised: 21-Mar-2015; Accepted: 12-Apr-2015; Online
first: 19-Apr-2015
Copyright: © 2015 Slavica Hristomanova Mitkovska, Trajkov D,
Petlichkovski A, Efinska-Mladenovska O, Mirko Spiroski.
This is an open-access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Hristomanova Mitkovska S
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Trajkov D
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Petlichkovski A
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Efinska-Mladenovska O
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Spiroski M
PubMed
- Hristomanova Mitkovska S
- Trajkov D
- Petlichkovski A
- Efinska-Mladenovska O
- Spiroski M
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