Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.044
Basic Science
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Tumor-Associated Macrophage
(TAM) and Angiogenesis in Human Colon Carcinoma
Manal A. Badawi, Dalia M. Abouelfadl, Sonia L. El-Sharkawy*,
Wafaa E. Abd El-Aal, Naglaa F. Abbas
Pathology Department, Medical Division, National Research Centre, Dokki,
Giza, Egypt
AIM: This study aimed to clarify how macrophages affect prognosis in
cancer colon and their association with tumor angiogenesis.
MATERIAL AND METHODS: Forty four biopsies of colon carcinoma and 15
of benign adenomatous polyps were investigated for macrophages infiltration
and microvessels density using immunohistochemistry and image morphometric
analysis. Macrophages and blood vessels were stained immunohistochemically
by CD68 and F-VIII markers respectively. The morphometric analysis was
carried out on the immunohistochemically stained slides using the Leica Qwin
500 Image Analyzer. Both of macrophages infiltration and microvessels
density were correlated with histological tumor grade, stage and lymph node
metastases and were correlated with each others.
RESULTS: Macrophage infiltration was significantly higher in
malignant cases than in benign polyps. High macrophage infiltration and
hypervascularity were significantly correlated with T-staging and lymph
nodes metastasis. A significant correlation was found between macrophage
infiltration and microvessels densitie in malignant tumors where
hypervascularity was significantly correlated with high macrophages
infiltration.
CONCLUSION: The significant correlation between macrophage
infiltration and tumor angiogenesis suggests an interaction between
macrophages and cancer cells stimulating microvessels formation, tumor
invasion and metastasis in colon cancer. We recommend that macrophages
infiltration should be evaluated to investigate their clinical value in
development of individualized therapeutic regimens for management of colon
carcinoma.
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Citation: Badawi MA, Abouelfadl DM, El-Sharkawy
SL, Abd El-Aal WE, Naglaa F. Abbas NF. Tumor-Associated Macrophage (TAM) and
Angiogenesis in Human Colon Carcinoma. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.044
Key words: Adenomatous polyps; cancer colon; macrophages;
angiogenesis; CD68; Factor VIII.
*Correspondence: Prof. Sonia El-Sharkawy. National Research Center,
Pathology, Dokki, Cairo 2478, Egypt. Primary E-Mail: elsharkawy60@hotmail.com
Received: 27-Mar-2015; Revised: 15-Apr-2015; Accepted: 16-Apr-2015; Online
first: 27-Apr-2015
Copyright: © 2015 Manal A. Badawi, Dalia M. Abouelfadl, Sonia L. El-Sharkawy,
Wafaa E. Abd El-Aal, Naglaa F. Abbas. This is an open access article
distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing
interests exist.
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Badawi MA
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Abouelfadl DM
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El-Sharkawy SL
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Abd El-Aal WE
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Naglaa F. Abbas NF
PubMed
- Badawi MA
- Abouelfadl DM
- El-Sharkawy SL
- Abd El-Aal WE
- Naglaa F. Abbas NF
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