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ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.031
Basic Science
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Investigation of Propolis’ Effect on Thiobarbituric
Acid Reactive Substances and Anti-Oxidant Enzyme Levels of Hippocampus in
Diabetic Rats Induced by Streptozotocin
Burcu Köksal*, Memet Hanifi Emre, Alaadin Polat
Inonu University, Faculty of Medicine, Department of Physiology, 44280
Malatya, Turkey
BACKGROUND: Propolis is an organic resinous viscous substance
collected from flower bud and plant sprig by bees. Propolis has a potential
treatment agent for oxidative damage caused by diabetes in hippocampus due
to its flavonoid and phenolic content.
AIM: In this study effect of propolis on thiobarbituric acid reactive
substances and anti-oxidative enzyme levels of hippocampus in diabetic rats
induced by streptozotocin was investigated.
MATERIALS AND METHODS: The study involved measuring levels of SOD,
CAT, GSH-Px and TBARs in hippocampus tissue of STZ-induced diabetic rats
(Adult Male Sprague Dawley rats) after applying propolis for one month. The
subjects of the study were composed of 51 rats randomly assigned to four
groups (Control, STZ, P+STZ and STZ+P). For analysis of data, Kruskal Wallis
Test was utilized.
RESULTS: The findings of the study showed that there were no
significant difference in the levels of TBARS, SOD, CAT and GSH-Px of
hippocampus across the groups.
CONCLUSION: Propolis application in four-week duration does not have
effect on TBARS, SOD, CAT and GSH-Px levels of hippocampus of diabetic rats.
These findings mean that more time for observing oxidative harms on
hippocampus is needed.
..................
Citation: Köksal B, Emre MH, Polat A.
Investigation of Propolis’ Effect on Thiobarbituric Acid Reactive Substances
and Anti-Oxidant Enzyme Levels of Hippocampus in Diabetic Rats Induced by
Streptozotocine. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.031
Key words: Diabetes; propolis; anti-oxidative enzymes;
streptozotocine; rats.
*Correspondence: Mr. Burcu Koksal. Inonu University, Department of
Physiology, Inonu University, Faculty of Medicine, Malatya 44280, Turkey.
Phone: +904223410660-1269. E-Mail: burkirimhan@gmail.com
Received: 21-Jan-2015; Revised: 22-Feb-2015; Accepted: 23-Feb-2015; Online
first: 09-Mar-2015
Copyright: © 2015 Burcu Köksal, Memet Hanifi Emre, Alaadin Polat.
This is an open access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited.
Competing Interests: The authors have declared that no competing
interests exist.
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