ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
Prediction of Gut Wall Integrity Loss in Viral
Gastroenteritis by Non-Invasive Marker
Hala G. Elnady1, Lobna S. Sherif1, Maysa T. Saleh1,
Inas R. El-Alameey1*, Mai M. Youssef1, Amal I. El
Shafie2, Iman Helwa3, Haiam Abdel Raouf3,
Ahmed N. EL-Taweel4
1Child Health Department, National Research Centre, Cairo,
Egypt; 2Health Radiation Research Department, National Centre for
Radiation Research and Technology, Cairo, Egypt; 3Immunogenetics
Department, National Research Centre, Cairo, Egypt; 4Environment
Virology Laboratory and Water Pollution Department, National Research
Centre, Cairo, Egypt
BACKGROUND: Intestinal fatty acid binding proteins (I-FABPs) are
mainly expressed in the intestinal villi, which are the initial site of
destruction in viral gastroenteritis.
AIM: This study was designed to assess serum I-FABPs as a predictor
of gut wall integrity loss in viral gastroenteritis.
PATIENTS AND METHODS: This case-control cross-sectional study was
conducted on 93 cases of acute viral gastroenteritis. Twenty-eight healthy
children matching in age were recruited as control group. Serum I-FABPs were
measured using ELISA technique. Viral detection and typing were done by PCR
for adenovirus, and by Reverse transcriptase PCR for rotavirus, astrovirus
RESULTS: Serum I-FABPs level was significantly higher in the cases
compared to the controls and was also higher in the 46 rotavirus
gastroenteritis cases compared to other viral gastroenteritis cases. Serum
I- FABPs level was significantly higher in severely dehydrated cases as
compared to mildly dehydrated ones (P=0.037).
CONCLUSION: Serum I-FABPs could be used as an early and sensitive
predictor marker of gut wall integrity loss in children with viral
gastroenteritis and its level can indicate case severity.
Citation: Elnady HG, Sherif LS, Saleh MT, El-Alameey
IR, Youssef MM, El Shafie AI, Helwa I, Abdel Raouf H, EL-Taweel AN.
Prediction of Gut Wall Integrity Loss in Viral Gastroenteritis by
Non-Invasive Marker. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.023
Key words: Viral Gastroenteritis; Gut Wall Integrity Loss; Non
Invasive Marker; Predicition.
*Correspondence: Dr. Inas R. El-Alameey. National Research Centre,
Child Health Department, Dokki,Cairo. Cairo P.O:12622, Egypt. Affiliation
ID: 60014618. Phone: 0201001858378. E-Mail: firstname.lastname@example.org
Received: 12-Jan-2015; Revised: 01-Feb-2015; Accepted: 02-Feb-2015; Online
Copyright: © 2015 Hala G. Elnady, Lobna S. Sherif, Maysa T. Saleh,
Inas R. El-Alameey, Mai M. Youssef, Amal I. El Shafie, Iman Helwa, Haiam
Abdel Raouf, Ahmed N. EL-Taweel. This is an open access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.
Competing Interests: The authors have declared that no competing
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El Shafie AI
Abdel Raouf H
- Elnady HG
- Sherif LS
- Saleh MT
- El-Alameey IR
- Youssef MM
- El Shafie AI
- Helwa I
- Abdel Raouf H
- EL-Taweel AN