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ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.021
Clinical Science
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Significance of Serum Cytokeratin-18 in Prediction of
Hepatocellular Carcinoma in Chronic Hepatitis C Infected Egyptian Patients
Wafaa El-Zefzafy1, Hanan Eltokhy2,
Nagwa Abd El-Ghaffar Mohamed3, Zakia Abu-Zahab4
1Faculty of Medicine for Girls Al-Azhar University, Tropical
Medicine, Cairo, Egypt; 2Faculty of Medicine for Girls Al-Azhar
University, Internal Medicine, Cairo, Egypt; 3Department of
Clinical and Chemical Pathology, National Research Center, AL-Tahreer
Street, AL-Dokki, Giza, Cairo 12622, Egypt; 4Faculty of Medicine
for Girls Al-Azhar University, Clinical Pathology, Cairo, Egypt
BACKGROUND: Hepatitis C virus is one of the most common etiologic
agents of chronic liver diseases, including liver cirrhosis and
hepatocellular carcinoma in which there is continuous inflammation and
regeneration of hepatocytes.Cytokeratin-18 (CK18) has been suggested to play
an important role in tumorigenesis of epithelial cancers.
AIM: Estimation of CK18 serum levels in patients with chronic viral
hepatitis C (CHCV) and hepatocellular carcinoma (HCC) and find the
relationship between their levels, the severity of the disease and the
development of HCC.
METHODS: We measured serum levels of CK18 in 60 Egyptian patients (30
with CHCV & 30 with HCC) and 30 healthy controls.
RESULTS: Patients with HCC had highly significant increased CK18
levels compared with CHCV patients, healthy controls. Cytokeratin-18 among
the three classes of Child-Pugh classification show highly significant
gradual increase from child A to C. Furthermore, In HCC there were positive
correlations between CK18 and with RBCs, ESR, and AFP.
CONCLUSION: CK18 is a sensitive indicator of the severity of liver
disease. Patients with CHCV infection can be followed up by measurement of
its serum level which can predict the development of HCC. The combination of
AFP and CK18 increased the sensitivity of detection for HCC.
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Citation: El-Zefzafy W, Eltokhy H, Abd El-Ghaffar
Mohamed NA, Abu-Zahab Z. Significance of Serum Cytokeratin-18 in Prediction
of Hepatocellular Carcinoma in Chronic Hepatitis C Infected Egyptian
Patients. OA Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.021
Key words: Cytokeratin-18; viral hepatitis; HCC; α-fetoprotein; tumor
marker.
*Correspondence: Assist. Prof. Wafaa Mohammed El-Zefzafy. Alzhraa
University Hospital, Tropical Medicine, Al-Abassiae, Cairo 11381, Egypt.
Phone: 00201142667256. E-Mail: wafaa_elzefzafy@yahoo.com
Received: 12-Jan-2015; Revised: 01-Feb-2015; Accepted: 02-Feb-2015; Online
first: 17-Feb-2015
Copyright: © 2015 Wafaa El-Zefzafy, Hanan Eltokhy, Nagwa Abd El-Ghaffar
Mohamed, Zakia Abu-Zahab. This is an open access article distributed under
the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.
Competing Interests: The authors have declared that no competing
interests exist.
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