ID Design 2012/DOOEL Skopje
Open Access Macedonian Journal of Medical Sciences.
http://dx.doi.org/10.3889/oamjms.2015.018
Clinical Science
|
|
Association between Serum Cortisol and DHEA-S Levels
and Response to Antipsychotic Treatment in Schizophrenia
Zoja Babinkostova1, Branislav Stefanovski1, Danijela
Janicevic-Ivanovska2, Valentina Samardziska1
1University Clinic of Psychiatry, Biological Psychiatry,
Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje,
Republic of Macedonia; 2Institute of Clinical Biochemistry,
Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje,
Republic of Macedonia
BACKGROUND: Previous studies suggested that alterations in serum
cortisol and DHEA-S levels may play a role in the pathophysiology of
schizophrenia.
AIM: To compare serum cortisol and DHEA-S levels between patients
with schizophrenia and healthy controls and to evaluate their association
with the response to antipsychotic treatment.
MATERIAL AND METHODS: In this clinical prospective study were
included 60 patients with schizophrenia and 40 healthy age and sex matched
control subjects. Clinical evaluation of patients was performed using the
Positive and Negative Symptom Scale. A questionnaire for socio-demographic
and clinical data collection was used. For the purposes of the study, the
examined group was divided in two subgroups: responders and nonresponders.
Serum cortisol and DHEA-S levels were measured at baseline in all
participants and after 3 and 6 weeks of the antipsychotic treatment in
patients with schizophrenia.
RESULTS: Patients with schizophrenia had significantly higher serum
cortisol and DHEA-S levels in comparison to the control group. Responders
had significantly higher serum cortisol and DHEA-S levels compared with
nonresponders.
CONCLUSION: Elevated serum cortisol and DHEA-S levels may play a role
in the pathophysiology of schizophrenia and they may be related to positive
response to antipsychotic treatment in patients with schizophrenia.
..................
Citation: Babinkostova Z, Stefanovski B,
Janicevic-Ivanovska D, Samardziska V. Association between Serum Cortisol and
DHEA-S Levels and Response to Antipsychotic Treatment in Schizophrenia. OA
Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.018
Key words: schizophrenia; cortisol; DHEA-S; responders; nonresponders.
*Correspondence: Dr. Zoja Babinkostova. University Clinic of
Psychiatry, Biological Psychiatry, ul.Vodnajnska 17, Skopje 1000, Macedonia.
E-Mail Address: zbabinkostova@yahoo.com
Received: 31-Jan-2015; Revised: 09-Feb-2015; Accepted: 10-Feb-2015; Online
first: 22-Feb-2015
Copyright: © 2015 Zoja Babinkostova, Branislav Stefanovski, Danijela
Janicevic-Ivanovska, Valentina Samardziska. This is an open access article
distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing
interests exist.
|
<
Previous
|
Next Article >
Table of contents
This Article
(free)
Full text (pdf)
Full text OnlineFirst (pdf)
Google Scholar
-
Babinkostova Z
-
Stefanovski B
-
Janicevic-Ivanovska D
-
Samardziska V
PubMed
- Babinkostova Z
- Stefanovski B
- Janicevic-Ivanovska D
- Samardziska V
|