Open Access Macedonian Journal of Medical Sciences.
Predictors of High Serum Casein
Antibody Levels among Malnourished Infants and Young Children with
Congenital Heart Disease
Inas R. El-Alameey1*, Hanaa Ahmed2,
Zeinab Monir1, Thanaa Rabah3, Ayman M. Abdel Gawad1
1National Research Centre, Child Health Department, Dokki, Cairo,
Egypt; 2National Research Centre, Hormones, Dokki, Cairo, Egypt;
3National Research Centre, Public Health and Community Medicine
Department, Dokki, Cairo, Egypt
BACKGROUND: Factors predictive of growth retardation and malnutrition
in patients with congenital heart disease remain unclear.
OBJECTIVES: This study aimed to measure antibody response to bovine
casein through assessing serum casein antibody levels in malnourished
patients three year or younger with CHD, and to determine its relationship
to gastrointestinal symptoms, anthropometric measures, and laboratory data.
SUBJECTS AND METHODS: This cross sectional case control study was
conducted in sixty patients with CHD aged 4 to 72 months. They were
subdivided into thirty patients with cyanotic and thirty patients with
acyanotic CHD compared with thirty apparently healthy children.
RESULTS: On comparison with controls, patients showed highly
significant lower anthropometric measures, calcium, iron, hemoglobin levels,
and higher serum levels of casein antibody, total iron binding capacity, and
alkaline phoshatase activity (P<0.000). Serum levels of casein antibody
showed significantly positive correlations with serum total iron binding
capacity and alkaline phosphatase activities and negatively correlated with
the age at onset of symptoms, anthropometric measures, serum calcium, and
CONCLUSION: Serum casein antibody levels play a significant role in
the pathogenesis of malnutrition. Encouragement of breast feeding and
avoidance of early cow's milk consumption could prevent the development of
antibody response to bovine casein.
Citation: El-Alameey IR, Ahmed H, Monir Z, Rabah
T, Abdel Gawad AM. Predictors of High Serum Casein Antibody Levels among
Malnourished Infants and Young Children with Congenital Heart Disease. OA
Maced J Med Sci. http://dx.doi.org/10.3889/oamjms.2015.015.
Key words: congenital heart disease; serum casein antibody;
malnourished infants; young children; predictors.
*Correspondence: Inas R. EL-Alameey. Address: Child Health
Department, National Research Centre, Dokki, Cairo, Egypt. P.O: 12622.
Affiliation ID: 60014618. Tel.: +20 1001858378. E-mail address: firstname.lastname@example.org
Received: 11-Dec-2014; Revised: 12-Jan-2015; Accepted: 13-Jan-2015; Online
Copyright: © 2015 Inas R. El-Alameey, Hanaa Ahmed, Zeinab Monir,
Thanaa Rabah, Ayman M. Abdel Gawad. This is an open access article
distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing
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Abdel Gawad AM
- El-Alameey IR
- Ahmed H
- Monir Z
- Rabah T
- Abdel Gawad AM