Malondialdehyde and Pentosidine in Young Type 1 Diabetic Patients

Soha M. Abd El Dayem¹, Ehsan A. Badawy El Sheikh², Sadek Saied Abdou², Mervat Harvi Agaibyi², Marwa Mahmoud²

¹Pediatrics Department, National Research Centre, Medical Physiology, El Tahrir St., Dokki Cairo, Cairo 12622, Egypt; ²Medical Biochemistry Department, Chemistry, Cairo, Egypt

Objective: To investigate whether advanced glycosylation end products (AGE) and oxidative stress are augmented in young patients with type 1 diabetes at early clinical stages of the disease.

Patients and Methods: The study included 50 patients with type 1 diabetes among those attending the endocrine clinic in National Research Centre and 30 healthy volunteers in the control group. Serum glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), triglycerides, serum creatinine concentrations, glycosylated hemoglobin (HbA1c), urinary albumin/ creatinine ratio, malondialdehyde and pentosidine were assessed.

Results: No significant difference was found between age of patients (12.0 ± 3.2 ) and controls (11.0 ± 1.2), P > 0.05. Blood glucose, HbA1c, urinary albumin / creatinine ratio, pentosidine and malondialdehyde were significantly higher in diabetic patients than controls. Pentosidine and malondialdehyde had a significant positive correlation with blood glucose, HbA1c and urinary albumin/creatinine ratio.

Conclusion: The present study indicates that accumulation of AGEs, whose formation is closely linked to oxidative stress, and resultant endothelial dysfunction may start early in the course of type 1 diabetes. This means that the risk of vascular complications may be present at an early age and that the best possible glycemic control should be emphasized from the diagnosis of diabetes.

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Citation: El Dayem SMD, El Sheikh EAB, Abdou SS, Agaibyi MH, Mahmoud M. Malondialdehyde and Pentosidine in Young Type 1 Diabetic Patients. Maced J Med Sci. 2012 Dec 15; 5(4):428-433. http://dx.doi.org/10.3889/MJMS.1957-5773.2012.0266.
Key words: Malondialdehyde; Pentosidine; type 1 diabetic patient.
Correspondence: Soha M. Abd El Dayem, Professor of Pediatrics. National Research Centre, Cairo, Egypt. E-mail: S_eldayem@Yahoo.com
Received: 15-Jan-2012; Revised: 01-Apr-2012; Accepted: 11-Apr-2012; Online first: 19-Nov-2012
Copyright: © 2012 El Dayem SMD. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
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