Omamuyovwi M Ijomone, Polycarp U Nwoha, Olayemi K Olaibi, Augustine U Obi, Margaret O Alese
 

Obafemi Awolowo University, Anatomy and Cell Biology, Ede Road, Ile-Ife, Osun 234, Nigeria

Aim: To investigate the protective effects of kolaviron on brain weight and behavioural performance and the histology of the hippocampus of adult Wistar rats following methamphetamine challenge.

Materials and Methods: Twenty four adult Wistar rats weighing between 150-200 g, randomly assigned into four groups of six each (Groups A, B, C, D) were used for this research. Group A served as control, while groups B and C were given single dose methamphetamine (10 mg/kg) intraperitoneally after group C was pre-treated with kolaviron (200 mg/kg) for 7 days and group D received cornoil (vehicle for kolaviron) only.

Results: High level of methamphetamine-induced stereotypic movement was observed, and the onset was delayed by kolaviron administration. Animals administered methamphetamine only, showed significantly poor behavioural performance on the water maze after treatment when compared to the other groups (P<0.05). Histological analysis revealed neuronal destruction of the pyramidal layer of the hippocampus following methamphetamine administration. Kolaviron to some extent prevented destruction of pyramidal cells of the hippocampus in pre-treated rats.

Conclusion: The present findings show the neuro-destructive effects of methamphetamine on hippocampal neurons and its ability to negatively affect behaviour and that kolaviron could prevent such behavioural deficit and also afford some protection to the hippocampus.

..................

Citation: Ijomone OM, Nwoha PU, Olaibi OK, Obi AU, Alese MO. Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of Garcinia kola, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity. Maced J Med Sci. 2012 Mar 15; 5(1):10-16. http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0203.
Key words: Kolaviron; Methamphetamine; Hippocampus; behavioural performance; neuroprotective.
Correspondence: Mr. Omamuyovwi Meashack Ijomone. Obafemi Awolowo University, Anatomy and Cell Biology, Ede Road, Ile-Ife, Osun 234, Nigeria. Phone: +234 703 1354971. E-Mail: godmamus@yahoo.com
Received: 01-Nov-2011; Accepted: 17-Nov-2011; Online first: 02-Dec-2011
Copyright: © 2011 Ijomone O. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The author have declared that no competing interests exist.
 

Abstract

Full text (html)

Full text (pdf)

Full text OnlineFirst (pdf)