Macedonian Journal of Medical Sciences. 2011 Dec
15;
4(4):380-387.
http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0198
Basic Science
Telfairia Occidentalis, a Prophylactic Medicine for Alcohol‘s Damaging Effect on the Testis
Edidiong Akang, Ademola Oremosu, Olufunke Dosumu, Adedayo Ejiwunmi
Department of Anatomy, College of Medicine, University of Lagos, P.M.B.
12003, Lagos, Nigeria
Background: Concerns have been expressed about rising cases of male
infertility. Studies have shown that alcohol impairs sexual performance and
desire in men. It also affects sperm count lowering it and contributing to
fertility problems.
Aim: This study investigated the role of Telfairia occidentals
in the protection of the testis against alcohol induced damage.
Material and Methods: 30 male Sprague-Dawley rats were divided into
five groups of 6 each. They were administered distilled water, 30% v/v of
ethanol at 2g/kg body weight, 200 mg/kg, 400 mg/kg and 600 mg/kg of
Telfairia occidentalis, for 8 weeks after which their blood samples were
collected for hormonal assay. The testis and cauda epididymis were also
excised for histology and semen analysis.
Results: Alcohol depleted the germinal epithelium of the testis but
animals that received Telfairia occidentalis showed a better germinal
epithelial lining and a significant increase in semen parameters and hormone
levels.
Conclusion: Telfairia occidentalis demonstrated a prophylactic
effect on alcohol induced testicular damage and has improved semen quality.
In addition, it also improved serum testosterone and luteinizing hormone
levels.
...................
Citation: Akang E, Oremosu A, Dosumu O, Ejiwunmi A. Telfairia
Occidentalis, a Prophylactic Medicine for Alcohol‘S Damaging Effect on the
Testis. Maced J Med Sci. 2011 Dec 15; 4(4):380-387.
http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0198.
Key words: Infertility; Ethanol; Serum testosterone; Luteinizing
hormone; seminiferous epithelium; sperm count; sperm motility.
Correspondence: Mr. Edidiong Nnamso Akang. Department of Anatomy,
College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria.
Phone: +2348065299278. E-Mail: eltyeddy@yahoo.com
Received: 11-May-2011; Revised: 28-Oct-2011; Accepted: 29-Oct-2011; Online
first: 29-Nov-2011
Copyright: © 2011 Akang E. This is an open access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.
Competing Interests: The authors have declared that no competing
interests exist.
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