Macedonian Journal of Medical Sciences
[International, Peer Reviewed]

About MJMS

Our policies

MJMS Online

For contributors

Services

Why publish in MJMS?
Editors
Boards
Indexing
Membership
Evaluation

Editorial & publishing policies
Competing interests policy 
Open access
Open access license

Publication fee
Reviewer guidelines

Online first
Current issue
Journal archive

Online first fact sheet
Free Registration
Contact

Guidelines  [pdf]
Online submission
Help for authors
Cover letter
Reviewers of MJMS

Reviewers Summary

Transliteration
Subscriptions

Advertising
Reprints and permissions
Resources
ICMJE Disclosure Form

 

Macedonian Journal of Medical Sciences. 2011 Dec 15; 4(4):380-387.

http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0198

Basic Science

 

Telfairia Occidentalis, a Prophylactic Medicine for Alcohol‘s Damaging Effect on the Testis
 

Edidiong Akang, Ademola Oremosu, Olufunke Dosumu, Adedayo Ejiwunmi


Department of Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria
 

Abstract

 

 

Background: Concerns have been expressed about rising cases of male infertility. Studies have shown that alcohol impairs sexual performance and desire in men. It also affects sperm count lowering it and contributing to fertility problems.

Aim: This study investigated the role of Telfairia occidentals in the protection of the testis against alcohol induced damage.

Material and Methods: 30 male Sprague-Dawley rats were divided into five groups of 6 each. They were administered distilled water, 30% v/v of ethanol at 2g/kg body weight, 200 mg/kg, 400 mg/kg and 600 mg/kg of Telfairia occidentalis, for 8 weeks after which their blood samples were collected for hormonal assay. The testis and cauda epididymis were also excised for histology and semen analysis.

Results: Alcohol depleted the germinal epithelium of the testis but animals that received Telfairia occidentalis showed a better germinal epithelial lining and a significant increase in semen parameters and hormone levels.

Conclusion: Telfairia occidentalis demonstrated a prophylactic effect on alcohol induced testicular damage and has improved semen quality. In addition, it also improved serum testosterone and luteinizing hormone levels.

...................

Citation: Akang E, Oremosu A, Dosumu O, Ejiwunmi A. Telfairia Occidentalis, a Prophylactic Medicine for Alcohol‘S Damaging Effect on the Testis. Maced J Med Sci. 2011 Dec 15; 4(4):380-387. http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0198.
Key words: Infertility; Ethanol; Serum testosterone; Luteinizing hormone; seminiferous epithelium; sperm count; sperm motility.
Correspondence: Mr. Edidiong Nnamso Akang. Department of Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria. Phone: +2348065299278. E-Mail: eltyeddy@yahoo.com
Received: 11-May-2011; Revised: 28-Oct-2011; Accepted: 29-Oct-2011; Online first: 29-Nov-2011
Copyright: © 2011 Akang E. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

 

< Previous | Next Article >

Table of contents

 

This Article (free)

Abstract

Full text (html)

Full text (pdf)

Full text OnlineFirst (pdf)

Citations

- DOAJ

- Index Copernicus

- Socol@r

Google Scholar

- Akang E
- Oremosu A
- Dosumu O
- Ejiwunmi A

PubMed

- Akang E
- Oremosu A
- Dosumu O
- Ejiwunmi A

 


Publication of the MJMS is supported by the Macedonian Ministry of Education and Sciences. Publisher: Institute of Immunobiology and Human GeneticsSkopje, Republic of Macedonia.

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

MJMS Print (ISSN 1857-5749) is an international peer-reviewed, Open Access journal published four times per year. MJMS Online (ISSN 1857-5773) offers free access to all articles.


Creative Commons Attribution LicenseAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.