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Macedonian Journal of Medical Sciences. 2011 Sep 30; 4(3):245-252.

http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0143

Basic Science

 

Adverse Effects of Organophosphorus Insecticides on Macrophage Activity in Persons at High Risk for Parasitic Infection
 

Ashour MN1, Mohamed ME2, Elsawy BM3

1National Research Centre, Medical Biochemistry, Al-tahrir Street, Dokki-Geza, Cairo 12311, Egypt; 2Faculty of Medicine, Zagazig University - Clinical Pathology and Hematology, Zagazig, Egypt; 3Faculty of Medicine, Cairo University - Anatomy, Cairo, Egypt

 

Abstract

 

Background: It has been suggested that acute exposure to pesticides altered the ability of macrophages to overcome the pathogen invasion.

Aim: To evaluate the levels of NO, IFN-gamma and arginase in both rats and patients with cutaneous leishmaniasis (CL) exposed daily to the chlorpyrifos (CPF) pesticide. Also, to evaluate the benefits of curcumin and / or arginine as a prophylactic agents.

Material and Methods: Plasma samples from 25 CL patients, 10 healthy control and CPF-treated rats, divided into five groups, were extracted. Also, PBMNCs recruited only from CL patients. out.

Results: A significant increase in the level of arginase coupled with a significant decrease in the levels of NO and INF-gamma were observed in CPF-treated animals. Restoration of the previous biochemical markers were significantly observed when a mixture of curcumin and arginine was used as a prophylactic remedy. In CL patients, a significant increase in the level of arginase activity was noticed. However, when curcumin is added to the cultural media containing active PBMNCs recruited from CL patients, a significant decrease in the level of NO associated with an increase in the arginase levels were noticed.

Conlusion: The negative effect of CPF on macrophage activity can be attenuated by oral intake a mixture of curcumin and arginine.

..................

Citation: Ashour MN, Mohamed ME, Elsawy BM. Adverse Effects of Organophosphorus Insecticides On Macrophage Activity In Persons at High Risk For Parasitic Infection. Maced J Med Sci. 2011 Sep 30; 4(3):245-252. http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0143.
Key words: Organophosphorus compounds; Macrophages; Cutaneous Leishmaniasis (CL); Curcumin; Arginine; Nitric oxide; Arginase; Interferon gamma.
Correspondence: Dr. Magdi Nabih Ashour. National Research Centre, Medical Biochemistry, Al-tahrir Street, Dokki-Geza, Cairo 12311, Egypt. E-Mail: magdiashour2009@yahoo.com
Received: 13-Apr-2011; Revised: 05-May-2011; Accepted: 22-May-2010; Online first: 30-Aug-2011
Copyright: © 2011 Ashour MN. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.

 

 

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