Neveen Abou El-Soud1, Nabila El-Laithy2, Gamila
El-Saeed2, Mohamed Salah Wahby3, Mona Khalil4,
Fatma Morsy5, Nermeen Shaffie5
1National Research Center, Complementary Medicine, Cairo, Giza
12311, Egypt; 2National Research Center, Medical Biochemistry,
Cairo, Giza 12311, Egypt; 3National Research Center, Cultivation
and Production of Aromatic and Medicinal Plants, Cairo, Giza 12311, Egypt;
4Gizan University, Medical Applied Science, Medical Chemistry,
Gizan, Saudi Arabia; 5National Research Center, Histology and
Pathology, Cairo, Giza 12311, Egypt
Background: Foeniculum vulgare Mill (F. Apiaceae) is an
ancient common herb and spice known to the ancient Egyptians and Greeks,
traditionally used as a carminative, a weak diuretic and lactation
stimulant.
Aim: To evaluate the essential oil of Foeniculum vulgare Mill
for its hypoglycaemic effect and antioxidant activity in addition to
histopathological study in streptozotocin induced diabetic rats.
Material and Methods: Rats were divided into 3 groups; normal
control, diabetic control, and diabetic group receiving orally Foeniculum
vulgare Mill essential oil (30 mg/kg bw).The dose of essential oil was
chosen according to its LD50. Serum glucose and whole blood glutathione
peroxidase were measured in addition to histopathological study of rats
kidney and pancreas.
Results: Ingestion of essential oil of Foeniculum vulgare Mill
to diabetic rats corrected the hyperglycemia from (162.5 ± 3.19 mg/dl) to
(81.97 ± 1.97 mg/dl) with p<0.05 and the activity of serum glutathione
peroxidase from (59.72 ± 2.78 U/g Hb) to (99.60 ± 6.38 U/g Hb) with p<0.05.
Also, improved the pathological changes noticed in their kidney and
pancreas.
Conclusion: Essential oil of Foeniculum vulgare Mill corrected
the hyperglycemia and pathological abnormalities in diabetic induced rats,
which could be in part through its antioxidative effect and restoring of
redox homeostasis. This makes the possibility of its inclusion in
antidiabetic drug industry.
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Citation: Abou El-Soud N, El-Laithy N, El-Saeed G, Salah Wahby
M,Khalil M, Morsy F, Shaffie N. Antidiabetic Activities of Foeniculum
Vulgare Mill. Essential Oil in Streptozotocin-Induced Diabetic Rats. Maced J
Med Sci. 2011 Jun 15; 4(2):139-146. doi.10.3889/MJMS.1957-5773.2011.0173.
Key words: diabetes; essential oil; experimental animal; antioxidant;
histopathology.
Correspondence: Prof. Neveen Helmy Abou El-Soud. National Research
Center, Complementary Medicine, 33-El Bohouth street- Dokki, Cairo, Giza
12311, Egypt. Phone: 0124359509. E-Mail: neveenster@gmail.com
Received: 14-Apr-2011; Revised: 08-May-2011; Accepted: 09-May-2011; Online
first: 16-May-2011
Copyright: © Abou El-Soud N. This is an open-access article
distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited.
Competing Interests: The author have declared that no competing
interests exist.
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