Macedonian Journal of Medical Sciences. 2011 Jun 15;
4(2):201-209.
doi:10.3889/MJMS.1857-5773.2011.0161
Review
Insulin Resistance in Liver Diseases
M Irshad1, Khushboo Irshad2, Prashant Nag1
1Clinical Biochemistry Division, Department of Laboratory
Medicine, All India Institute of Medical Sciences, New Delhi-110029, India;
2Department of Biochemistry, All India Institute of Medical
Sciences, New Delhi-110029, India
Present report gives a brief and consolidated review of insulin resistance
developed in chronic liver diseases. Insulin resistance remains an important
feature of chronic liver diseases and progresses disease towards
fibrogenesis. Of hepatitis viral infections, hepatitis C virus (HCV) was
reported to have a significant role in inducing insulin resistance. Both
viral particles as such, as well its structural components induce insulin
resistance. Hepatitis C virus core protein, specially, causes insulin
resistance via its direct action on insulin signaling cascade as well as by
inducing over expression of certain cytokines including TNF- a.
Insulin resistance has a direct relation with liver steatosis and oxidative
stress. Both steatosis and oxidative stress enhances insulin resistance and
vice-a-versa. Insulin resistance has widespread implications on metabolism
and needs its correction before planning therapeutic regimen in liver
diseases.
..................
Citation: Irshad M, Irshad K, Nag P. Insulin Resistance in Liver
Diseases. Maced J Med Sci. 2011 Jun 15; 4(2):201-209.
doi.10.3889/MJMS.1957-5773.2011.0161.
Key words: Insulin; steatosis; oxidative stress; HCV; HOMA-R.
Correspondence: Prof. M. Irshad. Clinical Biochemistry Division,
Department of Laboratory Medicine, A.I.I.M.S. New Delhi-110029, India.
E-mail: drirshad54@yahoo.com
Received: 28-Mar-2010; Revised: 28-Apr-2011; Accepted: 01-May-2011; Online
first: 10-May-2011
Copyright: © Irshad M. This is an open-access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.
Competing Interests: The author have declared that no competing
interests exist. |
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