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Macedonian Journal of Medical Sciences. 2011 Jun 15; 4(2):201-209.

doi:10.3889/MJMS.1857-5773.2011.0161

Review

 

Insulin Resistance in Liver Diseases
 

M Irshad1, Khushboo Irshad2, Prashant Nag1

1Clinical Biochemistry Division, Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi-110029, India; 2Department of Biochemistry, All India Institute of Medical Sciences, New Delhi-110029, India

 

Abstract

 

 

Present report gives a brief and consolidated review of insulin resistance developed in chronic liver diseases. Insulin resistance remains an important feature of chronic liver diseases and progresses disease towards fibrogenesis. Of hepatitis viral infections, hepatitis C virus (HCV) was reported to have a significant role in inducing insulin resistance. Both viral particles as such, as well its structural components induce insulin resistance. Hepatitis C virus core protein, specially, causes insulin resistance via its direct action on insulin signaling cascade as well as by inducing over expression of certain cytokines including TNF-a. Insulin resistance has a direct relation with liver steatosis and oxidative stress. Both steatosis and oxidative stress enhances insulin resistance and vice-a-versa. Insulin resistance has widespread implications on metabolism and needs its correction before planning therapeutic regimen in liver diseases.

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Citation: Irshad M, Irshad K, Nag P. Insulin Resistance in Liver Diseases. Maced J Med Sci. 2011 Jun 15; 4(2):201-209. doi.10.3889/MJMS.1957-5773.2011.0161.
Key words: Insulin; steatosis; oxidative stress; HCV; HOMA-R.
Correspondence: Prof. M. Irshad. Clinical Biochemistry Division, Department of Laboratory Medicine, A.I.I.M.S. New Delhi-110029, India. E-mail: drirshad54@yahoo.com
Received: 28-Mar-2010; Revised: 28-Apr-2011; Accepted: 01-May-2011; Online first: 10-May-2011
Copyright: © Irshad M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The author have declared that no competing interests exist.

 

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