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Macedonian Journal of Medical Sciences. 2011 Mar 15;
4(1):99-103.
doi:10.3889/MJMS.1857-5773.2011.0160
Case Report
Hyper IgE in a HIV Positive Patient - Case
Report
Slavica Hristomanova1, Violeta Grunevska2, Maragareta
Balabanova-Stefanova3, Dejan Trajkov1, Aleksandar
Petlichkovski1, Meri Kirijas1, Eli Djulejic1,
Aleksandar Senev1, Mirko Spiroski1
1Institut of Immunobiology and Human Genetics, Faculty of
Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of
Macedonia; 2University Clinic for Infective Diseases, Faculty of
Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of
Macedonia; 3University Clinic for Dermatovenerology, Faculty of
Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia
Background:
Hyperimmunoglobulinemia E Syndrome (HIES) is a primary immunodeficiency
syndrome associated with multiple abnormalities. Clinical manifestations of
atopic allergy, drug reactions, and increased IgE in serum were previously
reported during the course of human immunodeficiency virus (HIV) infection.
Case report: We herby describe the case of one 63 yrs old male
patient with a history of weight loss and diarrhoea, who was previously
treated for enterocolitis. He was also treated at the Dermatological Clinic
for herpes zoster infection and undiagnosed allergy. Microbiology tests
showed presence of Candida and Klebsiella pneumoniae in the patient’s sputum
which led to testing and confirmation of HIV/AIDS. After that, Lues was
diagnosed and blood sample was sent to our laboratory, to evaluate if this
atopic patients was sensitized to beta-lactam antibiotics. The results
showed increased level of total IgE for almost 12 times above normal ranges
and also allergy to ampicillin was revealed. Highly increased levels of
total IgE indicated the possibility for HIE Syndrome in this patient.
However the relationship of such findings to the immunologic abnormalities
found in patients with HIV is not entirely clear.
Conclusion: In conclusion, this is the first case of HIV positive
patient with hyper IgE immunoglobulinemia in the Republic of Macedonia. We
addressed the important laboratory findings and actual theories explaining
possible association between hyper IgE immunoglobulinemia and HIV/AIDS.
..................
Citation: Hristomanova S, Grunevska V,
Balabanova-Stefanova M, Trajkov D, Petlichkovski A, Kirijas M, Djulejic E,
Senev A, Spiroski M. Hyper IgE in a HIV Positive Patient - Case Report.
Maced J Med Sci. 2011 Mar 15; 4(1):99-103.
doi.10.3889/MJMS.1957-5773.2011.0160.
Key words: Hyper-IgE Syndrome; HIV infection; cytokines; Th1/Th2;
immunology.
Correspondence: Mirko Spiroski, MD, PhD. Institute of Immunobiology
and Human Genetics, Faculty of Medicine, University “Ss. Kiril and Metodij”,
1109 Skopje, PO Box 60, Republic of Macedonia. Tel.: +389-2-3110556; Fax:
+389-2-3110558. URL: http://www.iibhg.ukim.edu.mk/ e-mail: mspiroski@yahoo.com
Received: 16-Oct-2010; Revised: 31-Jan-2011; Accepted: 01-Feb-2011; Online
first: 02-Feb-2011
Copyright: © Hristomanova S. This is an open-access article
distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited.
Competing Interests: The author have declared that no competing
interests exist. |
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Hristomanova S
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Grunevska V
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Balabanova-Stefanova M
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Trajkov D
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Petlichkovski A
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Kirijas M
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Djulejic E
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Senev A
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Spiroski M
PubMed
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Hristomanova S
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Grunevska V
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Balabanova-Stefanova M
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Trajkov D
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Petlichkovski A
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Kirijas M
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Djulejic E
- Senev A
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Spiroski M
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