Osman Enaiat Ezat¹, Esmat Gamal², Adela Mahmood Gad¹, Eissa Somia Soliman¹, El El Abgeegy Mohammad³, Atteyate Hatia⁴ 

¹Internal Medicine Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt; ²Tropical Medicine Department, Faculty of Medicine,Cairo University, Cairo, Egypt; ³Internal Medicine Department, Ahmad Maher Educational Hospital, Ministry of Health, Cairo, Egypt; ⁴Cancer Institute, Cairo University, Cairo, Egypt

Background. The population in Egypt has a heavy burden of chronic liver disease, mostly due to chronic infection with hepatitis C virus.

Aim. To study prevalence and the factors affecting on recurrence of HCV genotype 4 in post-living donor liver transplantation (LDLT) among Egyptian patients.

Subjects and Methods. This study was conducted on 86 Egyptian patients who had HCV genotype 4 related end stage liver diseases. These patients (82 males and 4 females) with mean age 49. 21 ± 6.58 years were performed LDLT after exclusion of patients with active HBV or HCV with HIV. Liver enzymes, PCR for HCV RNA and histopathological studies were carried out to detect HCV recurrence.

Results. 29 out of 86 (33.7%) patients who received LDLT showed post-transplantation HCV recurrence within 3.89 years postoperative. Most of them showed HCV recurrence within the first year of post LDLT. The only two factors incriminated in recurrence are the viral load of recipient before transplantation and previous exposure for HBV.

Conclusion. One third of Egyptian HCV genotype 4 related diseases who received LDLT showed HCV recurrence. The viral load of recipient before transplantation and previous exposure for HBV are only two factors incriminated in recurrence.

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Abstract

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