Ahmad R, Hasnain A, Khan AH, Alam M. Presence of Circulating Lactate Dehydrogenase-Immunoglobulin G (LDH-IgG) Complex in the Sera of Post-Burn Patient. Maced J Med Sci. 2010;3(3):324-327. doi.10.3889/MJMS.1957-5773.2010.0140. [Eng Abstract]

Macedonian Journal of Medical Sciences [International Peer Reviewed]

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Abstract [Full-Text PDF] [Macedonian Abstract] [OnlineFirst Full-Text PDF]

Macedonian Journal of Medical Sciences. 2010 Sep 15; 3(3):324-327.

doi:10.3889/MJMS.1857-5773.2010.0140

Case Report

Presence of Circulating Lactate Dehydrogenase-Immunoglobulin G (LDH-IgG) Complex in the Sera of Post-Burn Patient

Riaz Ahmad¹, Absar-ul Hasnain¹, Arshad Hafeez Khan², Mumtaz Alam²

¹Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh-202 002 (U.P), India; ²Department of Plastic & Reconstructive Surgery, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh-202 002 (U.P), India

Lactate dehydrogenase (LDH) is an enzyme that belongs to the class oxidoreductase. It actively participates in the inter-conversion of lactate to pyruvate during anaerobic glycolysis in cell cytoplasm. Available literature suggests that there exist only five isoenzymes of LDH which on polyacrylamide gels (Native PAGE) resolve into five bands in normal healthy individuals. However, the presence of extra band in humans is either detected in reproductive tissues or during some pathological state. Here, we report a case in which an extra sixth band of LDH was visualized which forms a complex with IgG in the circulating sera of burn subject. The presence of LDH-IgG complex was confirmed in freshly collected sera using PAGE and immunological approaches. The complex get disappears from 2nd day onwards. The probable reason of the formation of this complex and its relation with the progression of the disease is discussed.

Key words: Lactate dehydrogenase (LDH); LDH-IgG complex; burn subject; PAGE; case report.

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